Ranking predictors of sustained viral response for chronic hepatitis C patients treated with pegylated interferon and ribavirin in Scotland

Hamish Innes; Sharon Hutchinson; Samual Allen; Diptendu Bhattacharyya; Peter Bramley; B. Carman; Toby E.S. Delahooke; John F. Dillon; David J. Goldberg; Nicholas Kennedy; Peter R. Mills; John Morris; Judith Morris; Chris Robertson; Adrian J. Stanley; Peter Hayes

doi:10.1097/MEG.0b013e32835201a4

Ranking predictors of sustained viral response for chronic hepatitis C patients treated with pegylated interferon and ribavirin in Scotland

Hamish Innes, Sharon Hutchinson, Samual Allen, Diptendu Bhattacharyya, Peter Bramley, B. Carman, Toby E.S. Delahooke, John F. Dillon, David J. Goldberg, Nicholas Kennedy, Peter R. Mills, John Morris, Judith Morris, Chris Robertson, Adrian J. Stanley, Peter Hayes

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Abstract

From the literature on the hepatitis C virus, the existence of a gap between a sustained virologic response (SVR) attainable in randomized clinical trials (RCTs) versus routine practice is not clear. Further, in terms of the pretreatment prediction of SVR, to date, studies have focused only on reporting the magnitude of association (MOA) between each predictor and an SVR. They fail to acknowledge that a predictor with a large MOA is of little value to clinicians if it has low variability in the treatment population.

Original language	English
Pages (from-to)	646–655
Number of pages	10
Journal	European Journal of Gastroenterology and Hepatology
Volume	24
Issue number	6
DOIs	https://doi.org/10.1097/MEG.0b013e32835201a4
Publication status	Published - 2012

Keywords

hepatitis C

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MEG.0b013e32835201a4

Cite this

Innes, H., Hutchinson, S., Allen, S., Bhattacharyya, D., Bramley, P., Carman, B., Delahooke, T. E. S., Dillon, J. F., Goldberg, D. J., Kennedy, N., Mills, P. R., Morris, J., Morris, J., Robertson, C., Stanley, A. J., & Hayes, P. (2012). Ranking predictors of sustained viral response for chronic hepatitis C patients treated with pegylated interferon and ribavirin in Scotland. European Journal of Gastroenterology and Hepatology, 24(6), 646–655. https://doi.org/10.1097/MEG.0b013e32835201a4

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title = "Ranking predictors of sustained viral response for chronic hepatitis C patients treated with pegylated interferon and ribavirin in Scotland",

abstract = "From the literature on the hepatitis C virus, the existence of a gap between a sustained virologic response (SVR) attainable in randomized clinical trials (RCTs) versus routine practice is not clear. Further, in terms of the pretreatment prediction of SVR, to date, studies have focused only on reporting the magnitude of association (MOA) between each predictor and an SVR. They fail to acknowledge that a predictor with a large MOA is of little value to clinicians if it has low variability in the treatment population.",

keywords = "hepatitis C",

author = "Hamish Innes and Sharon Hutchinson and Samual Allen and Diptendu Bhattacharyya and Peter Bramley and B. Carman and Delahooke, {Toby E.S.} and Dillon, {John F.} and Goldberg, {David J.} and Nicholas Kennedy and Mills, {Peter R.} and John Morris and Judith Morris and Chris Robertson and Stanley, {Adrian J.} and Peter Hayes",

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Innes, H , Hutchinson, S, Allen, S, Bhattacharyya, D, Bramley, P, Carman, B, Delahooke, TES, Dillon, JF, Goldberg, DJ, Kennedy, N, Mills, PR, Morris, J, Morris, J, Robertson, C, Stanley, AJ & Hayes, P 2012, 'Ranking predictors of sustained viral response for chronic hepatitis C patients treated with pegylated interferon and ribavirin in Scotland', European Journal of Gastroenterology and Hepatology, vol. 24, no. 6, pp. 646–655. https://doi.org/10.1097/MEG.0b013e32835201a4

TY - JOUR

T1 - Ranking predictors of sustained viral response for chronic hepatitis C patients treated with pegylated interferon and ribavirin in Scotland

AU - Innes, Hamish

AU - Hutchinson, Sharon

AU - Allen, Samual

AU - Bhattacharyya, Diptendu

AU - Bramley, Peter

AU - Carman, B.

AU - Delahooke, Toby E.S.

AU - Dillon, John F.

AU - Goldberg, David J.

AU - Kennedy, Nicholas

AU - Mills, Peter R.

AU - Morris, John

AU - Morris, Judith

AU - Robertson, Chris

AU - Stanley, Adrian J.

AU - Hayes, Peter

PY - 2012

Y1 - 2012

N2 - From the literature on the hepatitis C virus, the existence of a gap between a sustained virologic response (SVR) attainable in randomized clinical trials (RCTs) versus routine practice is not clear. Further, in terms of the pretreatment prediction of SVR, to date, studies have focused only on reporting the magnitude of association (MOA) between each predictor and an SVR. They fail to acknowledge that a predictor with a large MOA is of little value to clinicians if it has low variability in the treatment population.

AB - From the literature on the hepatitis C virus, the existence of a gap between a sustained virologic response (SVR) attainable in randomized clinical trials (RCTs) versus routine practice is not clear. Further, in terms of the pretreatment prediction of SVR, to date, studies have focused only on reporting the magnitude of association (MOA) between each predictor and an SVR. They fail to acknowledge that a predictor with a large MOA is of little value to clinicians if it has low variability in the treatment population.

KW - hepatitis C

U2 - 10.1097/MEG.0b013e32835201a4

DO - 10.1097/MEG.0b013e32835201a4

M3 - Article

SN - 0954-691X

VL - 24

SP - 646

EP - 655

JO - European Journal of Gastroenterology and Hepatology

JF - European Journal of Gastroenterology and Hepatology

IS - 6

ER -

Ranking predictors of sustained viral response for chronic hepatitis C patients treated with pegylated interferon and ribavirin in Scotland

Abstract

Keywords

UN SDGs

Documents and Links

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