Randomized clinical trial of four-layer and short-stretch compression bandages for venous leg ulcers (VenUS I)

EA Nelson, CP Iglesias, N Cullum, DJ Torgerson

Research output: Contribution to journalArticle

Abstract

Background:
A randomized clinical trial was undertaken to determine the relative effectiveness of four-layer and short-stretch bandaging for venous ulceration.

Methods:
A total of 387 adults with a venous ulcer, who were receiving leg ulcer treatment either in primary care or as a hospital outpatient, were recruited to this parallel-group open study and randomized to either four-layer or short-stretch bandages. Follow-up continued until the patient's reference leg was ulcer free or for a minimum of 12 months. The primary endpoint was time to complete healing of all ulcers on the reference leg. Secondary outcomes included proportion of ulcers healed, health-related quality of life, withdrawals and adverse events. Analysis was by intention to treat.

Results:
Unadjusted analysis identified no statistically significant difference in median time to healing: 92 days for four-layer and 126 days for short-stretch bandages. However, when prognostic factors were included in a Cox proportional hazards regression model, ulcers treated with the short-stretch bandage had a lower probability of healing than those treated with the four-layer bandage: hazard ratio 0·72 (95 per cent confidence interval 0·57 to 0·91). More adverse events and withdrawals were reported with the short-stretch bandage.

Conclusion:
Venous leg ulcers treated using a four-layer bandage healed more quickly than those treated with a short-stretch bandage.
Original languageEnglish
Pages (from-to)1292-1299
Number of pages8
JournalBritish Journal of Surgery
Volume91
Issue number10
DOIs
Publication statusPublished - 1 Oct 2004

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Keywords

  • randomised controlled trial
  • venous ulceration
  • four-layer bandages
  • short-stretch bandages

Cite this

Nelson, EA., Iglesias, CP., Cullum, N., & Torgerson, DJ. (2004). Randomized clinical trial of four-layer and short-stretch compression bandages for venous leg ulcers (VenUS I). British Journal of Surgery, 91(10), 1292-1299. https://doi.org/10.1002/bjs.4754