Raf Kinase inhibitor protein: mechanism of loss of expression and association with genomic instability

F. Al-Mulla, Suzanne Hagan, W. Al-Ali, A. I. Behbehani, M. S. Bitar, A. Dallol, W. Kolch

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Abstract

Raf kinase inhibitory protein (RKIP; also known as PEBP, for phosphatidylethanolamine-binding protein) is an endogenous inhibitor of the Raf– MAPK kinase (MEK)–MAP kinase pathway. It has emerged as a significant metastasis suppressor in a variety of human cancers including colorectal cancer (CRC) and was recently shown to regulate the spindle checkpoint in cultured cells. This study aims at correlating RKIP expression with chromosomal instability in colorectal cancer samples and identifies possible mechanisms of RKIP loss.

Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalJournal of Clinical Pathology
Volume61
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • Raf kinase inhibitory protein
  • MAP kinase pathway

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