Pseudomonas aeruginosa and their small diffusible extracellular molecules inhibit Aspergillus fumigatus biofilm formation

Eilidh Mowat, Ranjith Rajendran, Craig Williams, Elaine McCulloch, Brian Jones, Sue Lang, Gordon Ramage

Research output: Contribution to journalArticle

Abstract

Aspergillus fumigatus is often isolated from the lungs of cystic fibrosis (CF) patients, but unlike in severely immunocompromised individuals, the mortality rates are low. This suggests that competition from bacteria within the CF lung may be inhibitory. The purpose of this study was to investigate how Pseudomonas aeruginosa influences A. fumigatus conidial germination and biofilm formation. Aspergillus fumigatus biofilm formation was inhibited by direct contact with P. aeruginosa, but had no effect on preformed biofilm.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalFEMS Microbiology Letters
Volume313
Issue number2
DOIs
Publication statusPublished - 1 Dec 2010

Keywords

  • biofim formation
  • Aspergillus fumigatus
  • Pseudomonas aeruginosa

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