Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome

A. Chaudhuri; B. R. Condon; John W. Gow; D. Brennan; D. M. Hadley

Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome

A. Chaudhuri, B. R. Condon, John W. Gow, D. Brennan, D. M. Hadley

Glasgow Caledonian University

Research output: Contribution to journal › Article › peer-review

Abstract

Fatigue is a common symptom of neurological diseases that affect basal ganglia function.We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1HMRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex sexmatched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (po0.001). In the absence of regional structural or in£ammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.

Original language	English
Journal	NeuroReport
Publication status	Published - 1 Feb 2003

Keywords

proton magnetic resonance spectroscopy
chronic fatigue syndrome
basal ganglia
cell membrane
choline

Documents and Links

http://researchonline.gcu.ac.uk/sls/47

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title = "Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome",

abstract = "Fatigue is a common symptom of neurological diseases that affect basal ganglia function.We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1HMRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex sexmatched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (po0.001). In the absence of regional structural or in£ammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.",

keywords = "proton magnetic resonance spectroscopy, chronic fatigue syndrome, basal ganglia, cell membrane, choline",

author = "A. Chaudhuri and Condon, {B. R.} and Gow, {John W.} and D. Brennan and Hadley, {D. M.}",

note = "Originally published in: NeuroReport (2003), 14 (2), pp.225-228.",

year = "2003",

month = feb,

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language = "English",

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TY - JOUR

T1 - Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome

AU - Chaudhuri, A.

AU - Condon, B. R.

AU - Gow, John W.

AU - Brennan, D.

AU - Hadley, D. M.

N1 - Originally published in: NeuroReport (2003), 14 (2), pp.225-228.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Fatigue is a common symptom of neurological diseases that affect basal ganglia function.We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1HMRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex sexmatched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (po0.001). In the absence of regional structural or in£ammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.

AB - Fatigue is a common symptom of neurological diseases that affect basal ganglia function.We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1HMRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex sexmatched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (po0.001). In the absence of regional structural or in£ammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.

KW - proton magnetic resonance spectroscopy

KW - chronic fatigue syndrome

KW - basal ganglia

KW - cell membrane

KW - choline

M3 - Article

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

ER -