Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome

A. Chaudhuri, B. R. Condon, John W. Gow, D. Brennan, D. M. Hadley

Research output: Contribution to journalArticle

Abstract

Fatigue is a common symptom of neurological diseases that affect basal ganglia function.We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1HMRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex sexmatched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (po0.001). In the absence of regional structural or in£ammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.

Original languageEnglish
JournalNeuroReport
Publication statusPublished - 1 Feb 2003

Fingerprint

Chronic Fatigue Syndrome
Basal Ganglia
Choline
Fatigue
Basal Ganglia Diseases
Gliosis
Cell Membrane
Proton Magnetic Resonance Spectroscopy
Pathology

Keywords

  • proton magnetic resonance spectroscopy
  • chronic fatigue syndrome
  • basal ganglia
  • cell membrane
  • choline

Cite this

Chaudhuri, A., Condon, B. R., Gow, J. W., Brennan, D., & Hadley, D. M. (2003). Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome. NeuroReport.
Chaudhuri, A. ; Condon, B. R. ; Gow, John W. ; Brennan, D. ; Hadley, D. M. / Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome. In: NeuroReport. 2003.
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Chaudhuri, A, Condon, BR, Gow, JW, Brennan, D & Hadley, DM 2003, 'Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome', NeuroReport.

Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome. / Chaudhuri, A.; Condon, B. R.; Gow, John W.; Brennan, D.; Hadley, D. M.

In: NeuroReport, 01.02.2003.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome

AU - Chaudhuri, A.

AU - Condon, B. R.

AU - Gow, John W.

AU - Brennan, D.

AU - Hadley, D. M.

N1 - Originally published in: NeuroReport (2003), 14 (2), pp.225-228.

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Fatigue is a common symptom of neurological diseases that affect basal ganglia function.We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1HMRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex sexmatched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (po0.001). In the absence of regional structural or in£ammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.

AB - Fatigue is a common symptom of neurological diseases that affect basal ganglia function.We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1HMRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex sexmatched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (po0.001). In the absence of regional structural or in£ammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.

KW - proton magnetic resonance spectroscopy

KW - chronic fatigue syndrome

KW - basal ganglia

KW - cell membrane

KW - choline

M3 - Article

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

ER -

Chaudhuri A, Condon BR, Gow JW, Brennan D, Hadley DM. Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome. NeuroReport. 2003 Feb 1.