Prognostic factors for the two-year course of activity limitations in early osteoarthritis of the hip and/or knee

Jasmijn F.M. Holla, Martijn P.M. Steultjens, Leo D. Roorda, Martijn W. Heymans, Saskia Ten Wolde, Joost Dekker

Research output: Contribution to journalArticlepeer-review

Abstract

Objective

To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA).

Methods

The Cohort Hip& Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n = 1,002) with early OA-related knee and/or hip symptoms, was followed for 2 years. Participants completed questionnaires and underwent physical, laboratory, and radiographic examination. Regression models were used to examine whether baseline variables predicted the course of activity limitations as measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Analyses were performed separately for participants with knee symptoms and participants with hip symptoms.

Results

After 2 years of followup, activity limitations slightly decreased. Large between-subject variation was observed in WOMAC change scores. In participants with knee symptoms, young age, non-Western ethnicity, bilateral hip pain, morning stiffness in the knee, high comorbidity count, high body mass index, high bodily pain, poor general health perception, and pain coping strategy were associated with a poor 2-year outcome on activity limitations. In participants with hip symptoms, few activity limitations at baseline, bilateral hip pain, morning stiffness in the knee, high comorbidity count, low active hip flexion, poor general health perception, and pain coping strategy were associated with a poor 2-year outcome on activity limitations.

Conclusion

After 2 years of followup, large between-subject variation was observed in the course of activity limitations. The course of activity limitations is to some extent already predictable at an early stage of knee and hip OA.

Original languageEnglish
Pages (from-to)1415-1425
Number of pages11
JournalArthritis Care and Research
Volume62
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • hip osteoarthritis
  • Western Ontario and McMaster Universities Osteoarthritis Index
  • knee osteoarthritis
  • activity limitations

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