This book contains the Proceedings of the 17th International Conference on Evaluation of Novel Approaches to Software Engineering (ENASE 2022). This conference is sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC) and held in cooperation with the ACM Special Interest Group on Management Information Systems (ACM SIGMIS). This year’s ENASE is a Web-based event, due to the COVID-19 pandemic, taking place from April 25−26. The mission of ENASE is to be a prime international forum to discuss and publish research findings and IT industry experiences with relation to the evaluation of novel approaches to software engineering. The conference acknowledges necessary changes in systems and software thinking due to contemporary shifts of the computing paradigm to e-services, cloud computing, mobile connectivity, business processes, and societal participation. By comparing novel approaches with established traditional practices and by evaluating them against systems and software quality criteria, ENASE conferences advance knowledge and research in software engineering, including and emphasizing service-oriented, business-process driven, and ubiquitous mobile computing.