Abstract
Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE).
Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-a), interleukin 1-ß (IL1ß), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).
Results: Serum levels of IL6, IL1ß and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-a and LBP were not elevated.
Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.
Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-a), interleukin 1-ß (IL1ß), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).
Results: Serum levels of IL6, IL1ß and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-a and LBP were not elevated.
Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.
Original language | English |
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Pages (from-to) | 220-225 |
Number of pages | 6 |
Journal | Journal of Infection |
Volume | 55 |
Issue number | 3 |
Early online date | 22 Jun 2007 |
DOIs | |
Publication status | Published - Sep 2007 |
Keywords
- infective endocarditis
- inflammatory markers
- cytokines
- acute phase proteins