Pro-inflammatory cytokines IL6, TNF-a, IL1ß, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis

Richard W Watkin, Lucy V Harper, Ann B Vernallis, Susan Lang, Peter A Lambert, AM Ranasinghe, Tom SJ Elliott

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE).
Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-a), interleukin 1-ß (IL1ß), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).
Results: Serum levels of IL6, IL1ß and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-a and LBP were not elevated.
Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.
Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalJournal of Infection
Volume55
Issue number3
Early online date22 Jun 2007
DOIs
Publication statusPublished - Sep 2007

Keywords

  • infective endocarditis
  • inflammatory markers
  • cytokines
  • acute phase proteins

Fingerprint Dive into the research topics of 'Pro-inflammatory cytokines IL6, TNF-a, IL1ß, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis'. Together they form a unique fingerprint.

  • Cite this