Pro-inflammatory cytokines IL6, TNF-a, IL1ß, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis

Richard W Watkin; Lucy V  Harper; Ann B Vernallis; Susan Lang; Peter A Lambert; AM Ranasinghe; Tom SJ Elliott

doi:10.1016/j.jinf.2007.05.174

Pro-inflammatory cytokines IL6, TNF-a, IL1ß, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis

Richard W Watkin, Lucy V Harper, Ann B Vernallis, Susan Lang, Peter A Lambert, AM Ranasinghe, Tom SJ Elliott

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE).
Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-a), interleukin 1-ß (IL1ß), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).
Results: Serum levels of IL6, IL1ß and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-a and LBP were not elevated.
Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.

Original language	English
Pages (from-to)	220-225
Number of pages	6
Journal	Journal of Infection
Volume	55
Issue number	3
Early online date	22 Jun 2007
DOIs	https://doi.org/10.1016/j.jinf.2007.05.174
Publication status	Published - Sep 2007

Keywords

infective endocarditis
inflammatory markers
cytokines
acute phase proteins

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10.1016/j.jinf.2007.05.174

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Watkin, R. W., Harper, L. V., Vernallis, A. B., Lang, S., Lambert, P. A., Ranasinghe, AM., & Elliott, T. SJ. (2007). Pro-inflammatory cytokines IL6, TNF-a, IL1ß, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis. Journal of Infection, 55(3), 220-225. https://doi.org/10.1016/j.jinf.2007.05.174

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title = "Pro-inflammatory cytokines IL6, TNF-a, IL1{\ss}, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis",

abstract = "Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE).Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-a), interleukin 1-{\ss} (IL1{\ss}), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).Results: Serum levels of IL6, IL1{\ss} and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-a and LBP were not elevated.Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.",

keywords = "infective endocarditis, inflammatory markers, cytokines, acute phase proteins",

author = "Watkin, {Richard W} and Harper, {Lucy V} and Vernallis, {Ann B} and Susan Lang and Lambert, {Peter A} and AM Ranasinghe and Elliott, {Tom SJ}",

year = "2007",

month = sep,

doi = "10.1016/j.jinf.2007.05.174",

language = "English",

volume = "55",

pages = "220--225",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "Elsevier B.V.",

number = "3",

}

Pro-inflammatory cytokines IL6, TNF-a, IL1ß, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis. / Watkin, Richard W; Harper, Lucy V ; Vernallis, Ann B; Lang, Susan; Lambert, Peter A; Ranasinghe, AM; Elliott, Tom SJ.

In: Journal of Infection, Vol. 55, No. 3, 09.2007, p. 220-225.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Pro-inflammatory cytokines IL6, TNF-a, IL1ß, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis

AU - Watkin, Richard W

AU - Harper, Lucy V

AU - Vernallis, Ann B

AU - Lang, Susan

AU - Lambert, Peter A

AU - Ranasinghe, AM

AU - Elliott, Tom SJ

PY - 2007/9

Y1 - 2007/9

N2 - Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE).Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-a), interleukin 1-ß (IL1ß), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).Results: Serum levels of IL6, IL1ß and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-a and LBP were not elevated.Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.

AB - Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE).Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-a (TNF-a), interleukin 1-ß (IL1ß), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP).Results: Serum levels of IL6, IL1ß and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-a and LBP were not elevated.Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome.

KW - infective endocarditis

KW - inflammatory markers

KW - cytokines

KW - acute phase proteins

U2 - 10.1016/j.jinf.2007.05.174

DO - 10.1016/j.jinf.2007.05.174

M3 - Article

VL - 55

SP - 220

EP - 225

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 3

ER -