Preliminary toxicity assessment of pharmaceutical solutions with and without ferrate treatment

Srinath Patibandla, Jia-Qian Jiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Abstract

An emerging challenge to the scientific community and water industries is water contamination by various micro-pollutants which are pharmaceuticals, personal care products and endocrine disrupting chemicals. The main sources of these micro pollutants are waste waters from industrial effluent and sewage treatment plants. Recent advances in the knowledge have raised concerns about their effects on the human health and ecosystems. In this study, the efficiency of ferrate to remove low concentration of two pharmaceuticals (Simvastatin and Ivermectin, 10 and 100 µg/L) was investigated. Moreover, Zebra fish animal model was employed to access the acute toxicity before and after treatment with ferrate. Mortality, developmental changes (hatching, heart rate, total abnormalities count) and behaviour changes (swimming and activity) were recorded at all stages. Biochemical responses of Chloramphenicol acetyltransferase (CAT), Tumor necrosis factor (TNF), Interleukin 1 (IL-1) and B-cell lymphoma 2 (Bcl-2) were assessed. The study demonstrated that expression of CAT, TNF, IL-1 and Bcl-2 genes were affected after exposing zebra fish embryos to low concentration pharmaceuticals for 5 days (120 hours post fertilization). Simvastatin significantly increased the expression of anti-oxidant gene (CAT) and decreased the expression of Immune related TNF gene and apoptosis related Bcl-2 gene. Ivermectin showed significant change of expression of CAT and Bcl-2 genes. Ferrate reduced the toxicity of pharmaceuticals by partially removing them during the treatment process.
Original languageEnglish
Title of host publicationCEST2017 Proceedings
Publication statusPublished - 30 Sep 2017

Publication series

Name
ISSN (Print)1106-5516

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Pharmaceutical Solutions
Chloramphenicol O-Acetyltransferase
B-Cell Lymphoma
Ivermectin
Simvastatin
Tumor Necrosis Factor-alpha
Genes
Zebrafish
Interleukin-1
Pharmaceutical Preparations
Endocrine Disruptors
Pharmaceutical Services
Water
Waste Water
Sewage
Fertilization
Oxidants
Ecosystem
Industry
Embryonic Structures

Keywords

  • toxicity assessment
  • ferrate treatment technology

Cite this

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title = "Preliminary toxicity assessment of pharmaceutical solutions with and without ferrate treatment",
abstract = "An emerging challenge to the scientific community and water industries is water contamination by various micro-pollutants which are pharmaceuticals, personal care products and endocrine disrupting chemicals. The main sources of these micro pollutants are waste waters from industrial effluent and sewage treatment plants. Recent advances in the knowledge have raised concerns about their effects on the human health and ecosystems. In this study, the efficiency of ferrate to remove low concentration of two pharmaceuticals (Simvastatin and Ivermectin, 10 and 100 µg/L) was investigated. Moreover, Zebra fish animal model was employed to access the acute toxicity before and after treatment with ferrate. Mortality, developmental changes (hatching, heart rate, total abnormalities count) and behaviour changes (swimming and activity) were recorded at all stages. Biochemical responses of Chloramphenicol acetyltransferase (CAT), Tumor necrosis factor (TNF), Interleukin 1 (IL-1) and B-cell lymphoma 2 (Bcl-2) were assessed. The study demonstrated that expression of CAT, TNF, IL-1 and Bcl-2 genes were affected after exposing zebra fish embryos to low concentration pharmaceuticals for 5 days (120 hours post fertilization). Simvastatin significantly increased the expression of anti-oxidant gene (CAT) and decreased the expression of Immune related TNF gene and apoptosis related Bcl-2 gene. Ivermectin showed significant change of expression of CAT and Bcl-2 genes. Ferrate reduced the toxicity of pharmaceuticals by partially removing them during the treatment process.",
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Preliminary toxicity assessment of pharmaceutical solutions with and without ferrate treatment. / Patibandla, Srinath; Jiang, Jia-Qian.

CEST2017 Proceedings. 2017.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

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AU - Patibandla, Srinath

AU - Jiang, Jia-Qian

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PY - 2017/9/30

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AB - An emerging challenge to the scientific community and water industries is water contamination by various micro-pollutants which are pharmaceuticals, personal care products and endocrine disrupting chemicals. The main sources of these micro pollutants are waste waters from industrial effluent and sewage treatment plants. Recent advances in the knowledge have raised concerns about their effects on the human health and ecosystems. In this study, the efficiency of ferrate to remove low concentration of two pharmaceuticals (Simvastatin and Ivermectin, 10 and 100 µg/L) was investigated. Moreover, Zebra fish animal model was employed to access the acute toxicity before and after treatment with ferrate. Mortality, developmental changes (hatching, heart rate, total abnormalities count) and behaviour changes (swimming and activity) were recorded at all stages. Biochemical responses of Chloramphenicol acetyltransferase (CAT), Tumor necrosis factor (TNF), Interleukin 1 (IL-1) and B-cell lymphoma 2 (Bcl-2) were assessed. The study demonstrated that expression of CAT, TNF, IL-1 and Bcl-2 genes were affected after exposing zebra fish embryos to low concentration pharmaceuticals for 5 days (120 hours post fertilization). Simvastatin significantly increased the expression of anti-oxidant gene (CAT) and decreased the expression of Immune related TNF gene and apoptosis related Bcl-2 gene. Ivermectin showed significant change of expression of CAT and Bcl-2 genes. Ferrate reduced the toxicity of pharmaceuticals by partially removing them during the treatment process.

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M3 - Conference contribution

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