Potential zoonotic infection of porcine endogenous retrovirus in xenotransplantation

Giada Mattiuzzo, Yasuhiro Takeuchi, Linda Scobie

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Porcine endogenous retrovirus (PERV) is considered the major biosafety issue in xenotransplantation. Several techniques have been employed for the analysis of the PERV status in the animal donor and for the assessment of PERV transmission/infection in the xenograft recipient. In this chapter, methods to assess the expression of PERV and the potential for PERV transmission from a donor animal are described in addition to the identification of relevant loci within the porcine genome.
Original languageEnglish
Title of host publicationXenotransplantation
Subtitle of host publicationMethods in Molecular Biology
EditorsC. Costa, R. Máñez
PublisherHumana Press
Pages263-279
Number of pages16
ISBN (Print)9781617798443
DOIs
Publication statusPublished - 2012

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745

Keywords

  • zoonosis
  • retrovirus
  • porcine cell biology
  • xenotransplantation

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  • Cite this

    Mattiuzzo, G., Takeuchi, Y., & Scobie, L. (2012). Potential zoonotic infection of porcine endogenous retrovirus in xenotransplantation. In C. Costa, & R. Máñez (Eds.), Xenotransplantation : Methods in Molecular Biology (pp. 263-279). (Methods in Molecular Biology ). Humana Press. https://doi.org/10.1007/978-1-61779-845-0_17