Porcine endogenous retrovirus (PERV) is considered the major biosafety issue in xenotransplantation. Several techniques have been employed for the analysis of the PERV status in the animal donor and for the assessment of PERV transmission/infection in the xenograft recipient. In this chapter, methods to assess the expression of PERV and the potential for PERV transmission from a donor animal are described in addition to the identification of relevant loci within the porcine genome.
|Title of host publication||Xenotransplantation |
|Subtitle of host publication||Methods in Molecular Biology|
|Editors||C. Costa, R. Máñez|
|Number of pages||16|
|Publication status||Published - 2012|
|Name||Methods in Molecular Biology |
- porcine cell biology