Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd

O. Garkavenko; S. Wynyard; D. Nathu; M. Muzina; Z. Muzina; Linda Scobie; R. Hector; M. C. Croxson

doi:10.1016/j.transproceed.2008.01.051

Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd

O. Garkavenko, S. Wynyard, D. Nathu, M. Muzina, Z. Muzina, Linda Scobie, R. Hector, M. C. Croxson

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs.

Original language	English
Pages (from-to)	590-593
Number of pages	4
Journal	Transplantation Proceedings
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.transproceed.2008.01.051
Publication status	Published - 1 Mar 2008

Keywords

retrovirus
cell transplantation
pigs

Documents and Links

10.1016/j.transproceed.2008.01.051

http://researchonline.gcu.ac.uk/sls/300

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title = "Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd",

abstract = "Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses{\textquoteright} epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs.",

keywords = "retrovirus, cell transplantation, pigs",

author = "O. Garkavenko and S. Wynyard and D. Nathu and M. Muzina and Z. Muzina and Linda Scobie and R. Hector and Croxson, {M. C.}",

note = "Originally published in: Transplantation Proceedings (2008), 40 (2), pp.590-593.",

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doi = "10.1016/j.transproceed.2008.01.051",

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TY - JOUR

T1 - Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd

AU - Garkavenko, O.

AU - Wynyard, S.

AU - Nathu, D.

AU - Muzina, M.

AU - Muzina, Z.

AU - Scobie, Linda

AU - Hector, R.

AU - Croxson, M. C.

N1 - Originally published in: Transplantation Proceedings (2008), 40 (2), pp.590-593.

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs.

AB - Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs.

KW - retrovirus

KW - cell transplantation

KW - pigs

U2 - 10.1016/j.transproceed.2008.01.051

DO - 10.1016/j.transproceed.2008.01.051

M3 - Article

VL - 40

SP - 590

EP - 593

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 2

ER -