Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer’s disease

Gillian Hamilton, Farzana Samedi, Jo Knight, Nicola Archer, Catherine Foy, Sarah Walter, Dragana Turic, Luke Jehu, Pamela Moore, Paul Hollingworth, Michael C. O'Donovan, Julie Williams, Michael J. Owen, Simon Lovestone, John Powell

Research output: Contribution to journalArticle

Abstract

The ¿4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.
Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalNeuroscience Letters
Volume401
Issue number1-2
DOIs
Publication statusPublished - 2006

Fingerprint

Alzheimer Disease
Phosphates
Genes
Single Nucleotide Polymorphism
Alleles
Tensins
DNA

Keywords

  • late-onset Alzheimer's disease
  • PTEN
  • GSK3
  • polymorphism
  • DNA pooling

Cite this

Hamilton, Gillian ; Samedi, Farzana ; Knight, Jo ; Archer, Nicola ; Foy, Catherine ; Walter, Sarah ; Turic, Dragana ; Jehu, Luke ; Moore, Pamela ; Hollingworth, Paul ; O'Donovan, Michael C. ; Williams, Julie ; Owen, Michael J. ; Lovestone, Simon ; Powell, John. / Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer’s disease. In: Neuroscience Letters. 2006 ; Vol. 401, No. 1-2. pp. 77-80.
@article{84cc6b3b2dd449fba9e21ae7d9a0493d,
title = "Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer’s disease",
abstract = "The ¿4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.",
keywords = "late-onset Alzheimer's disease, PTEN, GSK3, polymorphism, DNA pooling",
author = "Gillian Hamilton and Farzana Samedi and Jo Knight and Nicola Archer and Catherine Foy and Sarah Walter and Dragana Turic and Luke Jehu and Pamela Moore and Paul Hollingworth and O'Donovan, {Michael C.} and Julie Williams and Owen, {Michael J.} and Simon Lovestone and John Powell",
year = "2006",
doi = "10.1016/j.neulet.2006.03.021",
language = "English",
volume = "401",
pages = "77--80",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier B.V.",
number = "1-2",

}

Hamilton, G, Samedi, F, Knight, J, Archer, N, Foy, C, Walter, S, Turic, D, Jehu, L, Moore, P, Hollingworth, P, O'Donovan, MC, Williams, J, Owen, MJ, Lovestone, S & Powell, J 2006, 'Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer’s disease', Neuroscience Letters, vol. 401, no. 1-2, pp. 77-80. https://doi.org/10.1016/j.neulet.2006.03.021

Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer’s disease. / Hamilton, Gillian; Samedi, Farzana; Knight, Jo; Archer, Nicola; Foy, Catherine; Walter, Sarah; Turic, Dragana; Jehu, Luke; Moore, Pamela; Hollingworth, Paul ; O'Donovan, Michael C.; Williams, Julie; Owen, Michael J.; Lovestone, Simon; Powell, John.

In: Neuroscience Letters, Vol. 401, No. 1-2, 2006, p. 77-80.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer’s disease

AU - Hamilton, Gillian

AU - Samedi, Farzana

AU - Knight, Jo

AU - Archer, Nicola

AU - Foy, Catherine

AU - Walter, Sarah

AU - Turic, Dragana

AU - Jehu, Luke

AU - Moore, Pamela

AU - Hollingworth, Paul

AU - O'Donovan, Michael C.

AU - Williams, Julie

AU - Owen, Michael J.

AU - Lovestone, Simon

AU - Powell, John

PY - 2006

Y1 - 2006

N2 - The ¿4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.

AB - The ¿4 allele of the APOE locus is the only confirmed risk factor for late-onset Alzheimer's disease (LOAD). The phosphate and tensin homolog (PTEN) gene is both a biological and positional candidate gene for LOAD. Eight polymorphisms spanning this gene were selected from dbSNP and genotyped in pooled DNA samples of both cases and controls. No evidence for association with LOAD was obtained in this study although further investigation revealed low levels of linkage disequlibrium (LD) between the genotyped SNPs. Our results suggest that it is unlikely that genetic variation within the PTEN gene contributes to risk of LOAD.

KW - late-onset Alzheimer's disease

KW - PTEN

KW - GSK3

KW - polymorphism

KW - DNA pooling

U2 - 10.1016/j.neulet.2006.03.021

DO - 10.1016/j.neulet.2006.03.021

M3 - Article

VL - 401

SP - 77

EP - 80

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -