Phase-dependent antifungal activity against Aspergillus fumigatus developing multicellular filamentous biofilms

Eilidh Mowat, Sue Lang, Craig Williams, Elaine McCulloch, Brian Jones, Gordon Ramage

Research output: Contribution to journalArticle

Abstract

Aspergillus fumigatus undergoes morphological transition throughout its growth and development. These changes have direct implications for the effectiveness of antifungal treatment. Here we report the in vitro antifungal activity of voriconazole, amphotericin B and caspofungin against three specific phases of multicellular development of A. fumigatus. A. fumigatus conidia were propagated for 8, 12 and 24 h prior to antifungal challenge. The resultant activity of the three agents tested was determined using an XTT reduction assay to assess both endpoint and time–kill susceptibility profiles.

Original languageEnglish
Pages (from-to)1281-1284
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume62
Issue number6
DOIs
Publication statusPublished - Sep 2008

Keywords

  • Aspergillus fumigatus
  • biofilms
  • antifungal activity

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