Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography

Justyna M. Płotka*, Marek Biziuk, Calum Morrison, Jacek Namieśnik

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

106 Citations (Scopus)

Abstract

The supercritical fluid is an excellent choice as the chromatographic mobile phase because it allows rapid separation with high efficiency and applications involving enantioresolution are common. Supercritical fluid chromatography (SFC) is increasingly used for analytical, semi-preparative and preparative purification of chiral compounds, including production of enantiomers that are mainly encountered during drug development. SFC can be used as an alternative to HPLC for many drug substances, so it is gaining popularity in the pharmaceutical industry. The main advantages of SFC in separating chiral pharmaceuticals are: high speed, short analysis time, limited environmental impact and high efficiency. The reduction in the use of organic solvents has cost, health, and safety benefits. Due to these advantages, SFC fulfills all the requirements of Green Analytical Chemistry approaches. In this article, we present application of SFC as a tool for chiral separation of pharmaceuticals and drugs of abuse.

Original languageEnglish
Pages (from-to)74-89
Number of pages16
JournalTrAC - Trends in Analytical Chemistry
Volume56
Early online date8 Feb 2014
DOIs
Publication statusPublished - Apr 2014
Externally publishedYes

Keywords

  • Chiral drug
  • Chiral pharmaceutical
  • Chiral selector
  • Chiral separation
  • Chiral stationary phase
  • Drugs of abuse
  • Enantioseparation
  • Green analytical chemistry
  • Pharmaceutical analysis
  • Supercritical fluid chromatography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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