@article{403dba580f414e8aa1e9d491e1149f12,
title = "Persistence of HIV-1 transmitted drug resistance mutations",
abstract = "There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive. The rate at which mutations became undetectable was estimated using exponential regression accounting for interval censoring. Most thymidine analogue mutations (TAMs) and T215 revertants (but not T215F/Y) were found to be highly stable, with NNRTI and PI mutations being relatively less persistent. Our estimates are important for informing HIV transmission models.",
keywords = "HIV-1, mutations, persistence, resistance, transmitted",
author = "Hannah Castro and Deenan Pillay and Patricia Cane and David Asboe and Valentina Cambiano and Andrew Phillips and Dunn, {David T.} and {UK Collaborative Group on HIV Drug Resistance} and David Goldberg",
note = "Financial support. This work was supported by the UK Medical Research Council (grant G0900274) and the European Community{\textquoteright}s 7th framework programme (FP7/2007–2013) under the Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN; project 223131). Acknowledgments. We thank the UK Collaborative HIV Cohort Study and the UK Register of HIV Seroconverters for providing demographic and clinical information for this study. UK HIV Drug Resistance Database Steering Committee: Celia Aitken, Gartnavel General Hospital, Glasgow; David Asboe, Anton Pozniak, Chelsea & Westminster Hospital, London; Daniel Webster, Royal Free NHS Trust, London; Patricia Cane, Health Protection Agency, Porton Down; Hannah Castro, David Dunn, David Dolling, Esther Fearnhill, Kholoud Porter, MRC Clinical Trials Unit, London; David Chadwick, South Tees Hospitals NHS Trust, Middlesbrough; Duncan Churchill, Brighton and Sussex University Hospitals NHS Trust; Duncan Clark, St Bartholomew{\textquoteright}s and The London NHS Trust; Simon Collins, HIV i-Base, London; Valerie Delpech, Health Protection Agency, Centre for Infections, London; Anna Maria Geretti, University of Liverpool; David Goldberg, Health Protection Scotland, Glasgow; Antony Hale, Leeds Teaching Hospitals NHS Trust; St{\'e}phane Hu{\'e}, University College London; Steve Kaye, Imperial College London; Paul Kellam, Wellcome Trust Sanger Institute and UCL Medical School; Linda Lazarus, Expert Advisory Group on AIDS Secretariat, Health Protection Agency, London; Andrew Leigh-Brown, University of Edinburgh; Nicola Mackie, Imperial NHS Trust; Chloe Orkin, St. Bartholomew{\textquoteright}s Hospital, London; Philip Rice, St George{\textquoteright}s Healthcare Trust, London; Deenan Pillay, Andrew Phillips, Caroline Sabin, University College London Medical School; Erasmus Smit, Health Protection Agency, Birmingham Heartlands Hospital; Kate Templeton, Royal Infirmary of Edinburgh; Peter Tilston, Manchester Royal Infirmary; William Tong, Guy{\textquoteright}s and St. Thomas{\textquoteright} NHS Foundation Trust, London; Ian Williams, Mortimer Market Centre, London; Hongyi Zhang, Addenbrooke{\textquoteright}s Hospital, Cambridge; Mark Zuckerman, King{\textquoteright}s College Hospital, London.",
year = "2013",
month = nov,
day = "1",
doi = "10.1093/infdis/jit345",
language = "English",
volume = "208",
pages = "1459--1463",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",
}
