Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor

Annette Graham; Neil Hogg; Balaraman Kalyanaraman; Vanessa O'Leary; Victor Darley-Usmar; Salvador Moncada

doi:10.1016/0014-5793(93)80269-Z

Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor

Annette Graham, Neil Hogg, Balaraman Kalyanaraman, Vanessa O'Leary, Victor Darley-Usmar^*, Salvador Moncada

^*Corresponding author for this work

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

259 Citations (Scopus)

Abstract

Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of α-tocopherol to α-tocopherol quinone.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	FEBS Letters
Volume	330
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(93)80269-Z
Publication status	Published - 13 Sept 1993

Keywords

atherosclerosis
low-density lipoprotein
macrophage
peroxynitrite

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(93)80269-Z

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title = "Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor",

abstract = "Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of α-tocopherol to α-tocopherol quinone.",

keywords = "atherosclerosis, low-density lipoprotein, macrophage, peroxynitrite",

author = "Annette Graham and Neil Hogg and Balaraman Kalyanaraman and Vanessa O'Leary and Victor Darley-Usmar and Salvador Moncada",

year = "1993",

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doi = "10.1016/0014-5793(93)80269-Z",

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T1 - Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor

AU - Graham, Annette

AU - Hogg, Neil

AU - Kalyanaraman, Balaraman

AU - O'Leary, Vanessa

AU - Darley-Usmar, Victor

AU - Moncada, Salvador

PY - 1993/9/13

Y1 - 1993/9/13

N2 - Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of α-tocopherol to α-tocopherol quinone.

AB - Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of α-tocopherol to α-tocopherol quinone.

KW - atherosclerosis

KW - low-density lipoprotein

KW - macrophage

KW - peroxynitrite

U2 - 10.1016/0014-5793(93)80269-Z

DO - 10.1016/0014-5793(93)80269-Z

M3 - Article

C2 - 8365489

AN - SCOPUS:0027162279

SN - 0014-5793

VL - 330

SP - 181

EP - 185

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor

Abstract

Keywords

ASJC Scopus subject areas

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