Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk

Adrian D. Wood; Anna A. Strachan; Frank Thies; Lorna S. Aucott; David M. Reid; Antonia C. Hardcastle; Alexandra Mavroeidi; William G. Simpson; Garry G. Duthie; Helen M. Macdonald

doi:10.1017/S0007114514001962

Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk

Adrian D. Wood, Anna A. Strachan, Frank Thies, Lorna S. Aucott, David M. Reid, Antonia C. Hardcastle, Alexandra Mavroeidi, William G. Simpson, Garry G. Duthie, Helen M. Macdonald

Research output: Contribution to journal › Article › peer-review

Abstract

Dietary modification may affect inflammatory processes and protect against chronic disease. In the present study, we examined the
relationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemic
inflammation in a 10-year longitudinal study of Scottish postmenopausal women. Diet was assessed by FFQ during 1997–2000 (n 3237,
mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007–11 for follow-up. Diet was assessed
by FFQ (n 1682) and blood was collected for the analysis of serum high-sensitivity C-reactive protein (hs-CRP), IL-6, serum amyloid A,
E-selectin, lipid profile and dietary biomarkers (carotenoids, tocopherols and retinol). Dietary pattern and dietary biomarker (serum carotenoid)
components were generated by principal components analysis. A past ‘prudent’ dietary pattern predicted serum concentrations of
hs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P¼0·002 and P¼0·001, respectively; ANCOVA). Contemporary
dietary patterns were also associated with inflammatory biomarkers. The concentrations of hs-CRP and IL-6 decreased across the quintiles
of the ‘prudent’ dietary pattern (P¼0·030 and P¼0·006, respectively). hs-CRP concentration increased across the quintiles of a ‘meatdominated’
dietary pattern (P¼0·001). Inflammatory biomarker concentrations decreased markedly across the quintiles of carotenoid
component score (P,0·001 for hs-CRP and IL-6, and P¼0·016 for E-selectin; ANCOVA). Prudent dietary pattern and carotenoid component
scores were negatively associated with serum hs-CRP concentration (unstandardised b for prudent component: 20·053, 95% CI 20·102,
20·003; carotenoid component: 20·183, 95% CI 20·233, 20·134) independent of study covariates. A prudent dietary pattern (which
reflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta and wine, in addition to fruit and vegetable consumption) and a
serum carotenoid profile characteristic of a fruit and vegetable-rich diet are associated with lower concentrations of intermediary markers
that are indicative of CVD risk reduction.

Original language	English
Pages (from-to)	1341-1352
Number of pages	12
Journal	British Journal of Nutrition
Volume	112
Issue number	8
DOIs	https://doi.org/10.1017/S0007114514001962
Publication status	Published - Oct 2014

Keywords

dietary patterns
carotenoids
systemic inflammation
CVD risk
postmenopausal women
longitudinal studies

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10.1017/S0007114514001962

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Wood, A. D., Strachan, A. A., Thies, F., Aucott, L. S., Reid, D. M., Hardcastle, A. C., Mavroeidi, A., Simpson, W. G., Duthie, G. G., & Macdonald, H. M. (2014). Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk. British Journal of Nutrition, 112(8), 1341-1352. https://doi.org/10.1017/S0007114514001962

Wood, Adrian D. ; Strachan, Anna A. ; Thies, Frank ; Aucott, Lorna S. ; Reid, David M. ; Hardcastle, Antonia C. ; Mavroeidi, Alexandra ; Simpson, William G. ; Duthie, Garry G. ; Macdonald, Helen M. / Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk. In: British Journal of Nutrition. 2014 ; Vol. 112, No. 8. pp. 1341-1352.

@article{347e149bddbf4244bfda595a83b9ff15,

title = "Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk",

abstract = "Dietary modification may affect inflammatory processes and protect against chronic disease. In the present study, we examined therelationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemicinflammation in a 10-year longitudinal study of Scottish postmenopausal women. Diet was assessed by FFQ during 1997–2000 (n 3237,mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007–11 for follow-up. Diet was assessedby FFQ (n 1682) and blood was collected for the analysis of serum high-sensitivity C-reactive protein (hs-CRP), IL-6, serum amyloid A,E-selectin, lipid profile and dietary biomarkers (carotenoids, tocopherols and retinol). Dietary pattern and dietary biomarker (serum carotenoid)components were generated by principal components analysis. A past {\textquoteleft}prudent{\textquoteright} dietary pattern predicted serum concentrations ofhs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P¼0·002 and P¼0·001, respectively; ANCOVA). Contemporarydietary patterns were also associated with inflammatory biomarkers. The concentrations of hs-CRP and IL-6 decreased across the quintilesof the {\textquoteleft}prudent{\textquoteright} dietary pattern (P¼0·030 and P¼0·006, respectively). hs-CRP concentration increased across the quintiles of a {\textquoteleft}meatdominated{\textquoteright}dietary pattern (P¼0·001). Inflammatory biomarker concentrations decreased markedly across the quintiles of carotenoidcomponent score (P,0·001 for hs-CRP and IL-6, and P¼0·016 for E-selectin; ANCOVA). Prudent dietary pattern and carotenoid componentscores were negatively associated with serum hs-CRP concentration (unstandardised b for prudent component: 20·053, 95% CI 20·102,20·003; carotenoid component: 20·183, 95% CI 20·233, 20·134) independent of study covariates. A prudent dietary pattern (whichreflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta and wine, in addition to fruit and vegetable consumption) and aserum carotenoid profile characteristic of a fruit and vegetable-rich diet are associated with lower concentrations of intermediary markersthat are indicative of CVD risk reduction.",

keywords = "dietary patterns, carotenoids, systemic inflammation, CVD risk, postmenopausal women, longitudinal studies",

author = "Wood, {Adrian D.} and Strachan, {Anna A.} and Frank Thies and Aucott, {Lorna S.} and Reid, {David M.} and Hardcastle, {Antonia C.} and Alexandra Mavroeidi and Simpson, {William G.} and Duthie, {Garry G.} and Macdonald, {Helen M.}",

year = "2014",

month = oct,

doi = "10.1017/S0007114514001962",

language = "English",

volume = "112",

pages = "1341--1352",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "8",

}

Wood, AD, Strachan, AA, Thies, F, Aucott, LS, Reid, DM, Hardcastle, AC, Mavroeidi, A, Simpson, WG, Duthie, GG & Macdonald, HM 2014, 'Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk', British Journal of Nutrition, vol. 112, no. 8, pp. 1341-1352. https://doi.org/10.1017/S0007114514001962

Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk. / Wood, Adrian D.; Strachan, Anna A.; Thies, Frank; Aucott, Lorna S.; Reid, David M.; Hardcastle, Antonia C.; Mavroeidi, Alexandra; Simpson, William G.; Duthie, Garry G.; Macdonald, Helen M.

In: British Journal of Nutrition, Vol. 112, No. 8, 10.2014, p. 1341-1352.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk

AU - Wood, Adrian D.

AU - Strachan, Anna A.

AU - Thies, Frank

AU - Aucott, Lorna S.

AU - Reid, David M.

AU - Hardcastle, Antonia C.

AU - Mavroeidi, Alexandra

AU - Simpson, William G.

AU - Duthie, Garry G.

AU - Macdonald, Helen M.

PY - 2014/10

Y1 - 2014/10

N2 - Dietary modification may affect inflammatory processes and protect against chronic disease. In the present study, we examined therelationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemicinflammation in a 10-year longitudinal study of Scottish postmenopausal women. Diet was assessed by FFQ during 1997–2000 (n 3237,mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007–11 for follow-up. Diet was assessedby FFQ (n 1682) and blood was collected for the analysis of serum high-sensitivity C-reactive protein (hs-CRP), IL-6, serum amyloid A,E-selectin, lipid profile and dietary biomarkers (carotenoids, tocopherols and retinol). Dietary pattern and dietary biomarker (serum carotenoid)components were generated by principal components analysis. A past ‘prudent’ dietary pattern predicted serum concentrations ofhs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P¼0·002 and P¼0·001, respectively; ANCOVA). Contemporarydietary patterns were also associated with inflammatory biomarkers. The concentrations of hs-CRP and IL-6 decreased across the quintilesof the ‘prudent’ dietary pattern (P¼0·030 and P¼0·006, respectively). hs-CRP concentration increased across the quintiles of a ‘meatdominated’dietary pattern (P¼0·001). Inflammatory biomarker concentrations decreased markedly across the quintiles of carotenoidcomponent score (P,0·001 for hs-CRP and IL-6, and P¼0·016 for E-selectin; ANCOVA). Prudent dietary pattern and carotenoid componentscores were negatively associated with serum hs-CRP concentration (unstandardised b for prudent component: 20·053, 95% CI 20·102,20·003; carotenoid component: 20·183, 95% CI 20·233, 20·134) independent of study covariates. A prudent dietary pattern (whichreflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta and wine, in addition to fruit and vegetable consumption) and aserum carotenoid profile characteristic of a fruit and vegetable-rich diet are associated with lower concentrations of intermediary markersthat are indicative of CVD risk reduction.

AB - Dietary modification may affect inflammatory processes and protect against chronic disease. In the present study, we examined therelationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemicinflammation in a 10-year longitudinal study of Scottish postmenopausal women. Diet was assessed by FFQ during 1997–2000 (n 3237,mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007–11 for follow-up. Diet was assessedby FFQ (n 1682) and blood was collected for the analysis of serum high-sensitivity C-reactive protein (hs-CRP), IL-6, serum amyloid A,E-selectin, lipid profile and dietary biomarkers (carotenoids, tocopherols and retinol). Dietary pattern and dietary biomarker (serum carotenoid)components were generated by principal components analysis. A past ‘prudent’ dietary pattern predicted serum concentrations ofhs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P¼0·002 and P¼0·001, respectively; ANCOVA). Contemporarydietary patterns were also associated with inflammatory biomarkers. The concentrations of hs-CRP and IL-6 decreased across the quintilesof the ‘prudent’ dietary pattern (P¼0·030 and P¼0·006, respectively). hs-CRP concentration increased across the quintiles of a ‘meatdominated’dietary pattern (P¼0·001). Inflammatory biomarker concentrations decreased markedly across the quintiles of carotenoidcomponent score (P,0·001 for hs-CRP and IL-6, and P¼0·016 for E-selectin; ANCOVA). Prudent dietary pattern and carotenoid componentscores were negatively associated with serum hs-CRP concentration (unstandardised b for prudent component: 20·053, 95% CI 20·102,20·003; carotenoid component: 20·183, 95% CI 20·233, 20·134) independent of study covariates. A prudent dietary pattern (whichreflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta and wine, in addition to fruit and vegetable consumption) and aserum carotenoid profile characteristic of a fruit and vegetable-rich diet are associated with lower concentrations of intermediary markersthat are indicative of CVD risk reduction.

KW - dietary patterns

KW - carotenoids

KW - systemic inflammation

KW - CVD risk

KW - postmenopausal women

KW - longitudinal studies

U2 - 10.1017/S0007114514001962

DO - 10.1017/S0007114514001962

M3 - Article

VL - 112

SP - 1341

EP - 1352

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

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ER -