Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk

Adrian D. Wood, Anna A. Strachan, Frank Thies, Lorna S. Aucott, David M. Reid, Antonia C. Hardcastle, Alexandra Mavroeidi, William G. Simpson, Garry G. Duthie, Helen M. Macdonald

    Research output: Contribution to journalArticle

    Abstract

    Dietary modification may affect inflammatory processes and protect against chronic disease. In the present study, we examined the
    relationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemic
    inflammation in a 10-year longitudinal study of Scottish postmenopausal women. Diet was assessed by FFQ during 1997–2000 (n 3237,
    mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007–11 for follow-up. Diet was assessed
    by FFQ (n 1682) and blood was collected for the analysis of serum high-sensitivity C-reactive protein (hs-CRP), IL-6, serum amyloid A,
    E-selectin, lipid profile and dietary biomarkers (carotenoids, tocopherols and retinol). Dietary pattern and dietary biomarker (serum carotenoid)
    components were generated by principal components analysis. A past ‘prudent’ dietary pattern predicted serum concentrations of
    hs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P¼0·002 and P¼0·001, respectively; ANCOVA). Contemporary
    dietary patterns were also associated with inflammatory biomarkers. The concentrations of hs-CRP and IL-6 decreased across the quintiles
    of the ‘prudent’ dietary pattern (P¼0·030 and P¼0·006, respectively). hs-CRP concentration increased across the quintiles of a ‘meatdominated’
    dietary pattern (P¼0·001). Inflammatory biomarker concentrations decreased markedly across the quintiles of carotenoid
    component score (P,0·001 for hs-CRP and IL-6, and P¼0·016 for E-selectin; ANCOVA). Prudent dietary pattern and carotenoid component
    scores were negatively associated with serum hs-CRP concentration (unstandardised b for prudent component: 20·053, 95% CI 20·102,
    20·003; carotenoid component: 20·183, 95% CI 20·233, 20·134) independent of study covariates. A prudent dietary pattern (which
    reflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta and wine, in addition to fruit and vegetable consumption) and a
    serum carotenoid profile characteristic of a fruit and vegetable-rich diet are associated with lower concentrations of intermediary markers
    that are indicative of CVD risk reduction.
    Original languageEnglish
    Pages (from-to)1341-1352
    Number of pages12
    JournalBritish Journal of Nutrition
    Volume112
    Issue number8
    DOIs
    Publication statusPublished - Oct 2014

    Keywords

    • dietary patterns
    • carotenoids
    • systemic inflammation
    • CVD risk
    • postmenopausal women
    • longitudinal studies

    Fingerprint Dive into the research topics of 'Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk'. Together they form a unique fingerprint.

  • Cite this

    Wood, A. D., Strachan, A. A., Thies, F., Aucott, L. S., Reid, D. M., Hardcastle, A. C., Mavroeidi, A., Simpson, W. G., Duthie, G. G., & Macdonald, H. M. (2014). Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk. British Journal of Nutrition, 112(8), 1341-1352. https://doi.org/10.1017/S0007114514001962