Oxysterols and retinal degeneration

Xun Zhang, Reem Hasaballah Alhasani, Xinzhi Zhou, James Reilly, Zhihong Zeng, Niall Strang, Xinhua Shu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Retinal degeneration, characterised by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation that regulate cholesterol homeostasis in the retina. Preclinical and clinical studies have suggested a connection between oxysterols and retinal degeneration. Here, we summarise early and recent work related to retina oxysterol-producing enzymes and the distribution of oxysterols in the retina. We examine the impact of loss of oxysterol-producing enzymes on retinal pathology and explore the molecular mechanisms associated with the toxic or protective roles of individual oxysterols in different types of retinal degeneration. We conclude that increased efforts to better understand the oxysterol-associated pathophysiology will help in the development of effective retinal degeneration therapies. LINKED ARTICLES: This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.16/issuetoc.
Original languageEnglish
Pages (from-to)3205-3219
Number of pages15
JournalBritish Journal of Pharmacology
Volume178
Issue number16
Early online date27 Jan 2021
DOIs
Publication statusPublished - Aug 2021

Keywords

  • retinal degeneration
  • cholestrol
  • oxysterol
  • toxicity
  • therapy

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