Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast

Jon Godwin

Research output: Contribution to journalArticlepeer-review

484 Citations (Scopus)

Abstract

Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive cancer) by 15.2% (SE 1.6%, 12.9% vs 28.1% 2 P <.00001), and it was effective regardless of the age at diagnosis, extent of breast-conserving surgery, use of tamoxifen, method of DCIS detection, margin status, focality, grade, comedonecrosis, architecture, or tumor size. Jon Godwin is a member of the EBCTCG, which is the group author for this article.

Original languageEnglish
Pages (from-to)162-177
Number of pages16
JournalJNCI Monographs
Volume41
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • breast cancer
  • oncology
  • clinical trials
  • radiotherapy

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