Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI

Faye Borthwick, Janice M. Taylor, Chris Bartholomew, Annette Graham

Research output: Contribution to journalArticle

Abstract

In this study, we investigated the impact of enhancing cholesterol delivery to mitochondrial sterol 27-hydroxylase, via steroidogenic acute regulatory protein (StAR), on the expression of genes involved in macrophage cholesterol homeostasis and efflux of cholesterol to apolipoprotein (apo) AI.

Original languageEnglish
Pages (from-to)526-534
Number of pages9
JournalCardiovascular Research
Volume86
Issue number3
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • apolipoprotein
  • apoAI
  • cholesterol efflux
  • atherosclerosis

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