Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI

Faye Borthwick; Janice M. Taylor; Chris Bartholomew; Annette Graham

doi:10.1093/cvr/cvq015

Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI

Faye Borthwick, Janice M. Taylor, Chris Bartholomew, Annette Graham

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

In this study, we investigated the impact of enhancing cholesterol delivery to mitochondrial sterol 27-hydroxylase, via steroidogenic acute regulatory protein (StAR), on the expression of genes involved in macrophage cholesterol homeostasis and efflux of cholesterol to apolipoprotein (apo) AI.

Original language	English
Pages (from-to)	526-534
Number of pages	9
Journal	Cardiovascular Research
Volume	86
Issue number	3
DOIs	https://doi.org/10.1093/cvr/cvq015
Publication status	Published - 1 Jan 2010

Keywords

apolipoprotein
apoAI
cholesterol efflux
atherosclerosis

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10.1093/cvr/cvq015

Cite this

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title = "Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI",

abstract = "In this study, we investigated the impact of enhancing cholesterol delivery to mitochondrial sterol 27-hydroxylase, via steroidogenic acute regulatory protein (StAR), on the expression of genes involved in macrophage cholesterol homeostasis and efflux of cholesterol to apolipoprotein (apo) AI.",

keywords = "apolipoprotein, apoAI, cholesterol efflux, atherosclerosis",

author = "Faye Borthwick and Taylor, {Janice M.} and Chris Bartholomew and Annette Graham",

note = "Originally published in: Cardiovascular Research (2010), 86 (3), pp.526-534.",

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doi = "10.1093/cvr/cvq015",

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AU - Borthwick, Faye

AU - Taylor, Janice M.

AU - Bartholomew, Chris

AU - Graham, Annette

N1 - Originally published in: Cardiovascular Research (2010), 86 (3), pp.526-534.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - In this study, we investigated the impact of enhancing cholesterol delivery to mitochondrial sterol 27-hydroxylase, via steroidogenic acute regulatory protein (StAR), on the expression of genes involved in macrophage cholesterol homeostasis and efflux of cholesterol to apolipoprotein (apo) AI.

AB - In this study, we investigated the impact of enhancing cholesterol delivery to mitochondrial sterol 27-hydroxylase, via steroidogenic acute regulatory protein (StAR), on the expression of genes involved in macrophage cholesterol homeostasis and efflux of cholesterol to apolipoprotein (apo) AI.

KW - apolipoprotein

KW - apoAI

KW - cholesterol efflux

KW - atherosclerosis

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U2 - 10.1093/cvr/cvq015

DO - 10.1093/cvr/cvq015

M3 - Article

VL - 86

SP - 526

EP - 534

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -

Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI

Abstract

Keywords

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