Our current clinical understanding of Candida biofilms: where are we two decades on?

Gordon Ramage*, Elisa Borghi, Célia Fortuna Rodrigues, Ryan Kean, Craig Williams, Jose Lopez-Ribot

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
76 Downloads (Pure)

Abstract

Clinically we have been aware of the concept of Candida biofilms for many decades, though perhaps without the formal designation. Just over 20 years ago the subject emerged on the back of progress made from the bacterial biofilms, and academic progress pace has continued to mirror the bacterial biofilm community, albeit at a decreased volume. It is apparent that Candida species have a considerable capacity to colonize surfaces and interfaces and form tenacious biofilm structures, either alone or in mixed species communities. From the oral cavity, to the respiratory and genitourinary tracts, wounds, or in and around a plethora of biomedical devices, the scope of these infections is vast. These are highly tolerant to antifungal therapies that has a measurable impact on clinical management. This review aims to provide a comprehensive overight of our current clinical understanding of where these biofilms cause infections, and we discuss existing and emerging antifungal therapies and strategies.

Original languageEnglish
Pages (from-to)636-653
Number of pages18
JournalAPMIS
Volume131
Issue number11
Early online date18 Mar 2023
DOIs
Publication statusPublished - Nov 2023

Keywords

  • antifungals
  • biofilm
  • Candida
  • Clinical microbiology
  • fungi
  • yeast

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

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