Non-susceptibility of Escherichia coli, Klebsiella spp., Pseudomonas spp. and Streptococcus pneumoniae in the UK: temporal trends in England, Northern Ireland, Scotland and Wales

Rebecca Guy, Lourda Geoghegan, Maggie Heginbothom, Robin Howe, Berit Muller-Pebody, Jacqui S. Reilly, Julie Wilson, Camilla Wiuff, Tim Wyatt, Alan P. Johnson

Research output: Contribution to journalArticle

Abstract

Objectives: To monitor and compare trends in the non-susceptibility of bloodstream isolates of pathogens to key antibiotics in the constituent countries of the UK between 2010 and 2014.
Methods: Routinely generated antibiotic susceptibility test results for bloodstream isolates of Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas spp., Streptococcus pneumoniae and Staphylococcus aureus were collected from hospital microbiology laboratories in each country.
Results: With the exception of a decrease in the proportion of S. aureus that were MRSA, non-susceptibility to key antibiotics among the pathogens studied remained largely unchanged over the 5-year study period, with any increases in non-susceptibility being small. Although some inter-country variation in the proportions of non-susceptible isolates was seen, apart from MRSA the differences were generally small (<5%) and fluctuated from year to year, with no country showing consistently higher or lower rates of resistance.
Conclusions: Collation between the constituent countries of the UK allows an integrated approach to nationwide surveillance of antibiotic resistance.
Original languageEnglish
Pages (from-to)1564-1569
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume71
Issue number6
Early online date17 Feb 2016
DOIs
Publication statusPublished - Jun 2016

Keywords

  • Antibiotics
  • Staphylococcus aureus
  • antibiotic resistance
  • bacterial
  • klebsiella
  • klebsiella pneumoniae
  • streptococcus pneumoniae
  • pseudomonas
  • microbiology
  • pathogenic organism
  • escherichia coli
  • antimicrobial susceptibility
  • methicillin-resistant staphylococcus aureus
  • multi-antibiotic resistance
  • laboratory test finding
  • klebsiella oxytoca

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