NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy

Sarah Fox; Tom Wilkinson; Paul S. Wheatley; Bo Xiao; Russell E. Morris; Alistair D. Sutherland; John Simpson; Peter G. Barlow

doi:10.1016/j.actbio.2009.10.038

NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy

Sarah Fox, Tom Wilkinson, Paul S. Wheatley, Bo Xiao, Russell E. Morris, Alistair D. Sutherland, John Simpson, Peter G. Barlow

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchanged zeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn²⁺-exchanged zeolite material at a 50 wt.% composition in a polytetrafluoroethylene polymer.

Original language	English
Pages (from-to)	1515-1521
Number of pages	7
Journal	Acta Biomaterialia
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.actbio.2009.10.038
Publication status	Published - 1 Apr 2010

Keywords

zeolite materials
anti-bacterial agent
wound healing
nitric oxide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Documents and Links

10.1016/j.actbio.2009.10.038

Cite this

@article{1f893ab003ef43f7b336846aa4f312ff,

title = "NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy",

abstract = "Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchanged zeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchanged zeolite material at a 50 wt.% composition in a polytetrafluoroethylene polymer.",

keywords = "zeolite materials, anti-bacterial agent, wound healing, nitric oxide",

author = "Sarah Fox and Tom Wilkinson and Wheatley, {Paul S.} and Bo Xiao and Morris, {Russell E.} and Sutherland, {Alistair D.} and John Simpson and Barlow, {Peter G.}",

note = "<p>Originally published in: Acta Biomaterialia (2010), 6 (4), pp.1515-1521.</p>",

year = "2010",

month = apr,

day = "1",

doi = "10.1016/j.actbio.2009.10.038",

language = "English",

volume = "6",

pages = "1515--1521",

journal = "Acta Biomaterialia",

publisher = "Acta Materialia Inc",

number = "4",

}

TY - JOUR

T1 - NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy

AU - Fox, Sarah

AU - Wilkinson, Tom

AU - Wheatley, Paul S.

AU - Xiao, Bo

AU - Morris, Russell E.

AU - Sutherland, Alistair D.

AU - Simpson, John

AU - Barlow, Peter G.

N1 - <p>Originally published in: Acta Biomaterialia (2010), 6 (4), pp.1515-1521.</p>

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchanged zeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchanged zeolite material at a 50 wt.% composition in a polytetrafluoroethylene polymer.

AB - Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchanged zeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchanged zeolite material at a 50 wt.% composition in a polytetrafluoroethylene polymer.

KW - zeolite materials

KW - anti-bacterial agent

KW - wound healing

KW - nitric oxide

U2 - 10.1016/j.actbio.2009.10.038

DO - 10.1016/j.actbio.2009.10.038

M3 - Article

VL - 6

SP - 1515

EP - 1521

JO - Acta Biomaterialia

JF - Acta Biomaterialia

IS - 4

ER -

NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy

Abstract

Keywords

UN SDGs

Documents and Links

Fingerprint

Cite this