NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy

Sarah Fox, Tom Wilkinson, Paul S. Wheatley, Bo Xiao, Russell E. Morris, Alistair D. Sutherland, John Simpson, Peter G. Barlow

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchanged zeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchanged zeolite material at a 50 wt.% composition in a polytetrafluoroethylene polymer.

Original languageEnglish
Pages (from-to)1515-1521
Number of pages7
JournalActa Biomaterialia
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Apr 2010

Keywords

  • zeolite materials
  • anti-bacterial agent
  • wound healing
  • nitric oxide

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    Fox, S., Wilkinson, T., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A. D., Simpson, J., & Barlow, P. G. (2010). NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy. Acta Biomaterialia, 6(4), 1515-1521. https://doi.org/10.1016/j.actbio.2009.10.038