NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy

Sarah Fox, Tom Wilkinson, Paul S. Wheatley, Bo Xiao, Russell E. Morris, Alistair D. Sutherland, John Simpson, Peter G. Barlow

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchanged zeolites are nanoporous materials with high-capacity storage properties for gases such as NO. The NO stores are liberated upon contact with aqueous environments, thereby making them ideal candidates for use in biological and clinical settings. Here, we demonstrate the NO release capacity and powerful bactericidal properties of a novel NO-storing Zn2+-exchanged zeolite material at a 50 wt.% composition in a polytetrafluoroethylene polymer.

Original languageEnglish
Pages (from-to)1515-1521
Number of pages7
JournalActa Biomaterialia
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Apr 2010

Fingerprint

Zeolites
Nitric oxide
Nitric Oxide
Biological Phenomena
Polytetrafluoroethylene
Pathogens
Polytetrafluoroethylenes
Synaptic Transmission
Wound Healing
Transition metals
Blood Vessels
Polymers
Gases
Metals
Chemical analysis

Keywords

  • zeolite materials
  • anti-bacterial agent
  • wound healing
  • nitric oxide

Cite this

Fox, S., Wilkinson, T., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A. D., ... Barlow, P. G. (2010). NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy. Acta Biomaterialia, 6(4), 1515-1521. https://doi.org/10.1016/j.actbio.2009.10.038
Fox, Sarah ; Wilkinson, Tom ; Wheatley, Paul S. ; Xiao, Bo ; Morris, Russell E. ; Sutherland, Alistair D. ; Simpson, John ; Barlow, Peter G. / NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy. In: Acta Biomaterialia. 2010 ; Vol. 6, No. 4. pp. 1515-1521.
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Fox, S, Wilkinson, T, Wheatley, PS, Xiao, B, Morris, RE, Sutherland, AD, Simpson, J & Barlow, PG 2010, 'NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy', Acta Biomaterialia, vol. 6, no. 4, pp. 1515-1521. https://doi.org/10.1016/j.actbio.2009.10.038

NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy. / Fox, Sarah; Wilkinson, Tom; Wheatley, Paul S.; Xiao, Bo; Morris, Russell E.; Sutherland, Alistair D.; Simpson, John; Barlow, Peter G.

In: Acta Biomaterialia, Vol. 6, No. 4, 01.04.2010, p. 1515-1521.

Research output: Contribution to journalArticle

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T1 - NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy

AU - Fox, Sarah

AU - Wilkinson, Tom

AU - Wheatley, Paul S.

AU - Xiao, Bo

AU - Morris, Russell E.

AU - Sutherland, Alistair D.

AU - Simpson, John

AU - Barlow, Peter G.

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KW - zeolite materials

KW - anti-bacterial agent

KW - wound healing

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Fox S, Wilkinson T, Wheatley PS, Xiao B, Morris RE, Sutherland AD et al. NO-loaded Zn2+-exchanged zeolite materials: a potential bi-functional anti-bacterial strategy. Acta Biomaterialia. 2010 Apr 1;6(4):1515-1521. https://doi.org/10.1016/j.actbio.2009.10.038