New insights into pulmonary hypertension: a role for connexin-mediated signalling

Myo Htet, Jane E. Nally, Patricia E. Martin, Yvonne Dempsie*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Pulmonary hypertension is a serious clinical condition characterised by increased pulmonary arterial pressure. This can lead to right ventricular failure which can be fatal. Connexins are gap junction-forming membrane proteins which serve to exchange small molecules of less than 1 kD between cells. Connexins can also form hemi-channels connecting the intracellular and extracellular environments. Hemi-channels can mediate adenosine triphosphate release and are involved in autocrine and paracrine signalling. Recently, our group and others have identified evidence that connexin-mediated signalling may be involved in the pathogenesis of pulmonary hypertension. In this review, we discuss the evidence that dysregulated connexin-mediated signalling is associated with pulmonary hypertension.
Original languageEnglish
Article number379
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume23
Issue number1
DOIs
Publication statusPublished - 29 Dec 2021

Keywords

  • pulmonary hypertension; connexins; gap junctions; vascular remodelling; hypoxic vasoconstriction; vascular reactivity; right ventricular hypertrophy

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