New insights into pulmonary hypertension: a role for connexin-mediated signalling

Myo Htet, Jane E. Nally, Patricia E. Martin, Yvonne Dempsie*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
18 Downloads (Pure)


Pulmonary hypertension is a serious clinical condition characterised by increased pulmonary arterial pressure. This can lead to right ventricular failure which can be fatal. Connexins are gap junction-forming membrane proteins which serve to exchange small molecules of less than 1 kD between cells. Connexins can also form hemi-channels connecting the intracellular and extracellular environments. Hemi-channels can mediate adenosine triphosphate release and are involved in autocrine and paracrine signalling. Recently, our group and others have identified evidence that connexin-mediated signalling may be involved in the pathogenesis of pulmonary hypertension. In this review, we discuss the evidence that dysregulated connexin-mediated signalling is associated with pulmonary hypertension.
Original languageEnglish
Article number379
Number of pages11
JournalInternational Journal of Molecular Sciences
Issue number1
Publication statusPublished - 29 Dec 2021


  • pulmonary hypertension; connexins; gap junctions; vascular remodelling; hypoxic vasoconstriction; vascular reactivity; right ventricular hypertrophy
  • signal transduction
  • humans
  • hypertension, pulmonary/metabolism
  • gap junctions/metabolism
  • animals
  • connexins/metabolism
  • disease models, animal

ASJC Scopus subject areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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