Abstract
As well as acting as a neurotransmitter, serotonin is also involved in morphogenetic signalling during crucial phases of many
developmental and regenerative processes such as cleavage, migration and differentiation. Echinoderms display nervedependent
regenerative phenomena and serotonin is one of the main neural regulatory factors that have been identified
in them. The present work was designed to investigate the broad-spectrum involvement of this molecule in echinoderm regeneration,
focusing on arm regeneration in the crinoid Antedon mediterranea. We carried out specific in vivo exposure experiments
to selected anti-serotonergic drugs (a synthesis inhibitor: parachlorophenylalanine and a receptor antagonist:
methiothepin) and explored their possible effects on arm regeneration.
Original language | English |
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Pages (from-to) | 555-562 |
Number of pages | 8 |
Journal | Journal of the Marine Biological Association of the United Kingdom |
Volume | 90 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 2009 |
Keywords
- serotonin
- marine biology
- Echinoderms
- invertebrates