New evidence of serotonin involvement in the neurohumoral control of crinoid arm regeneration: effects of parachlorophenylanine and methiothepin

Michela Sugni, Iain Wilkie, Paolo Burighel, M. Daniela Candia Carnevali

Research output: Contribution to journalArticle

Abstract

As well as acting as a neurotransmitter, serotonin is also involved in morphogenetic signalling during crucial phases of many
developmental and regenerative processes such as cleavage, migration and differentiation. Echinoderms display nervedependent
regenerative phenomena and serotonin is one of the main neural regulatory factors that have been identified
in them. The present work was designed to investigate the broad-spectrum involvement of this molecule in echinoderm regeneration,
focusing on arm regeneration in the crinoid Antedon mediterranea. We carried out specific in vivo exposure experiments
to selected anti-serotonergic drugs (a synthesis inhibitor: parachlorophenylalanine and a receptor antagonist:
methiothepin) and explored their possible effects on arm regeneration.

Original languageEnglish
Pages (from-to)555-562
Number of pages8
JournalJournal of the Marine Biological Association of the United Kingdom
Volume90
Issue number3
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • serotonin
  • marine biology
  • Echinoderms
  • invertebrates

Fingerprint Dive into the research topics of 'New evidence of serotonin involvement in the neurohumoral control of crinoid arm regeneration: effects of parachlorophenylanine and methiothepin'. Together they form a unique fingerprint.

Cite this