Natural history of complications after intracerebral haemorrhage

Myzoon Ali, P. L. Lyden, Ralph Sacco, Ashfaq Shuaib, Kennedy R. Lees

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)


    Numerous trials of haemostatic and neuroprotective agents for intracerebral haemorrhage (ICH) have failed. We characterized the risk of complications after ICH in a trial-eligible patient population, to inform safety in future trials. We used the Virtual International Stroke Trials Archive database to identify placebo-treated patients with spontaneous ICH, who were not comatose at admission, where randomization took place within 4 h of symptom onset, and where serious complication and outcome data were available. We described the complications encountered and assessed whether the absence of common complications influenced attainment of good functional outcome (mRS =4) at 90 days using logistic regression.

    Original languageEnglish
    Pages (from-to)624-630
    Number of pages7
    JournalEuropean Journal of Neurology
    Issue number5
    Early online date19 Feb 2009
    Publication statusPublished - May 2009


    • intracerebral haemorrhage
    • stroke
    • clinical trials


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