National population prevalence of antibodies to SARS-CoV-2 among pregnant women in Scotland during the second wave of the COVID-19 pandemic: a prospective national serosurvey

A. McAuley*, P. Gousias, T. Hasan, L. Rashid, C. Richardson, G. Reid, K. Templeton, J. McGuire, H. Wise, L. McVicar, S. Jenks, R. Gunn, E. Dickson, S. J. Stock, A. Stockton, C. Waugh, R. Wood, J. McMenamin, C. Robertson, D. J. GoldbergN. E. Palmateer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
2 Downloads (Pure)

Abstract

Objectives: This study aimed to determine SARS-CoV-2 seroprevalence among pregnant women in the Scottish population during the second wave of theCOVID-19 pandemic. Study design: Prospective national serosurvey. Methods: We tested 13,428 residual samples retrieved from pregnant women participating in the first trimester combined ultrasound and biochemical screening for fetal trisomy across Scotland for SARSCoV-2 antibodies over a 6-month period from November 2020 to April 2021. Seroprevalence estimates were adjusted for the sensitivity and specificity of the assays and weighted to reference populations. Results: Seroprevalence rates in the antenatal samples significantly increased from 5.5% (95% confidence interval [CI] 4.7%e6.5%) in the 5-week period up to and including International Organization for Standardization(ISO) Week 51 (w/b Monday 14 December 2020) to 11.3% (95% CI 10.1%e12.6%) in the 5-week period up to and including ISO Week 14 (w/b Monday 5 April 2021).Increasing seroprevalence trends across the second wave were observed among all age groups. Conclusions: By the end of the second wave of the COVID-19pandemic, approximately one in 10 women tested around the end of the first trimester of pregnancy had antibodies to SARS-CoV-2, suggesting that the vast majority were still susceptible to COVID-19 as they progressed to the later stages of pregnancy, when risks from infection are elevated for both mother and baby.

Original languageEnglish
Pages (from-to)17-19
Number of pages3
JournalPublic Health
Volume199
Early online date16 Aug 2021
DOIs
Publication statusPublished - Oct 2021

Keywords

  • COVID-19
  • SARS-CoV-2
  • Pregnancy
  • Antenatal
  • Coronavirus
  • Seroprevalence
  • Serology
  • Antibodies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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