Modulation of the cellular microRNA landscape: contribution to the protective effects of High-Density Lipoproteins (HDL)

Annette Graham*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
26 Downloads (Pure)

Abstract

High-density lipoproteins (HDL) play an established role in protecting against cellular dysfunction in a variety of different disease contexts; however, harnessing this therapeutic potential has proved challenging due to the heterogeneous and relative instability of this lipoprotein and its variable cargo molecules. The purpose of this study is to examine the contribution of microRNA (miRNA; miR) sequences, either delivered directly or modulated endogenously, to these protective functions. This narrative review introduces the complex cargo carried by HDL, the protective functions associated with this lipoprotein, and the factors governing biogenesis, export and the uptake of microRNA. The possible mechanisms by which HDL can modulate the cellular miRNA landscape are considered, and the impact of key sequences modified by HDL is explored in diseases such as inflammation and immunity, wound healing, angiogenesis, dyslipidaemia, atherosclerosis and coronary heart disease, potentially offering new routes for therapeutic intervention.

Original languageEnglish
Article number1232
Number of pages21
JournalBiology
Volume12
Issue number9
Early online date13 Sept 2023
DOIs
Publication statusPublished - Sept 2023

Keywords

  • gene regulation
  • high-density lipoproteins
  • microRNA biogenesis
  • microRNA secretion
  • signal transduction

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences

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