Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages

Anne Marie Allen; Ann Graham

doi:10.1186/1476-511X-11-169

Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages

Anne Marie Allen, Ann Graham

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

37 Downloads (Pure)

Abstract

Mitochondrial DNA damage, increased production of reactive oxygen species and progressive respiratory chain dysfunction, together with increased deposition of cholesterol and cholesteryl esters, are hallmarks of atherosclerosis. This study investigated the role of mitochondrial function in regulation of macrophage cholesterol efflux to apolipoprotein A-I, by the addition of established pharmacological modulators of mitochondrial function.

Original language	English
Pages (from-to)	169
Number of pages	5
Journal	Lipids in Health and Disease
Volume	11
DOIs	https://doi.org/10.1186/1476-511X-11-169
Publication status	Published - Nov 2012

Keywords

mitochondria
DNA damage
atherosclerosis

Documents and Links

10.1186/1476-511X-11-169

Allen, A. M. & Graham, A. (2012) Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages
© 2012 Allen and Graham; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 719 KBLicence: CC BY

Cite this

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AB - Mitochondrial DNA damage, increased production of reactive oxygen species and progressive respiratory chain dysfunction, together with increased deposition of cholesterol and cholesteryl esters, are hallmarks of atherosclerosis. This study investigated the role of mitochondrial function in regulation of macrophage cholesterol efflux to apolipoprotein A-I, by the addition of established pharmacological modulators of mitochondrial function.

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KW - atherosclerosis

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Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages

Abstract

Keywords

Documents and Links

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