Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages

Anne Marie Allen, Ann Graham

Research output: Contribution to journalArticle

Abstract

Mitochondrial DNA damage, increased production of reactive oxygen species and progressive respiratory chain dysfunction, together with increased deposition of cholesterol and cholesteryl esters, are hallmarks of atherosclerosis. This study investigated the role of mitochondrial function in regulation of macrophage cholesterol efflux to apolipoprotein A-I, by the addition of established pharmacological modulators of mitochondrial function.
Original languageEnglish
Pages (from-to)169
Number of pages5
JournalLipids in Health and Disease
Volume11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • mitochondria
  • DNA damage
  • atherosclerosis

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