Mitochondrial (dys)function and regulation of macrophage cholesterol efflux

Anne Marie Allen, Janice Taylor, Ann Graham

Research output: Contribution to journalArticle

Abstract

Cholesterol trafficking from the outer to the cholesterol-poor inner mitochondrial membrane requires energized, polarized and actively respiring mitochondria, mediated by a highly regulated multimeric (140–200 kDa) protein complex comprising StAR (steroidogenic acute regulatory protein), mitochondrial TSPO (translocator protein), VDAC (voltage-dependent anion channel), ANT (adenine nucleotide transporter) and associated regulatory proteins. Mitochondrial cholesterol transport is rate-limiting in the CYP27A1 (sterol 27-hydroxylase)-dependent generation of oxysterol ligands for LXR (liver X receptor) transcription factors that regulate the expression of genes encoding proteins in the cholesterol efflux pathway, such as ABC transporters (ATP-binding cassette transporters) ABCA1 and ABCG1.
Original languageEnglish
Pages (from-to)505-509
Number of pages5
JournalClinical Science
Volume124
DOIs
Publication statusPublished - 2012

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Keywords

  • cholesterol
  • atherosclerosis
  • ATP binding
  • mitochondria

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