MicroRNA sequences modulated by beta cell lipid metabolism: implications for type 2 diabetes mellitus

Jamie M.R. Tarlton, Steven Patterson, Annette Graham*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Alterations in lipid metabolism within beta cells and islets contributes to dysfunction and apoptosis of beta cells, leading to loss of insulin secretion and the onset of type 2 diabetes. Over the last decade, there has been an explosion of interest in understanding the landscape of gene expression which influences beta cell function, including the importance of small non-coding microRNA sequences in this context. This review sought to identify the microRNA sequences regulated by metabolic challenges in beta cells and islets, their targets, highlight their function and assess their possible relevance as biomarkers of disease progression in diabetic individuals. Predictive analysis was used to explore networks of genes targeted by these microRNA sequences, which may offer new therapeutic strategies to protect beta cell function and delay the onset of type 2 diabetes.
Original languageEnglish
Article number534
Number of pages33
JournalBiology
Volume10
Issue number6
DOIs
Publication statusPublished - 15 Jun 2021

Keywords

  • Beta cells
  • MicroRNA
  • Islets
  • Lipotoxicity
  • Lipid

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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