Abstract
Thromboxane A2 and endothelial dysfunction are implicated in the development of pulmonary hypertension. The receptor-transduction pathway for U46619 (9,11-dideoxy-9a, 11a-methanoepoxy prostaglandin F2a)-induced contraction was examined in endothelium-intact (E+) and denuded (E-) rat pulmonary artery rings. Artery rings were mounted on a wire myograph under a tension of 7–7.5 mN at 37°C and gassed with 95% O2/5% CO2. Isometric recording was made by using Powerlab data collection and Chart 5 software.
Original language | English |
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Pages (from-to) | 581-596 |
Number of pages | 16 |
Journal | British Journal of Pharmacology |
Volume | 157 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jun 2009 |
Keywords
- chloride channels
- endothelium
- thromboxane A2
- rat pulmonary arteries