Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium

C. McKenzie, Allan MacDonald, Angus M. Shaw

Research output: Contribution to journalArticle

Abstract

Thromboxane A2 and endothelial dysfunction are implicated in the development of pulmonary hypertension. The receptor-transduction pathway for U46619 (9,11-dideoxy-9a, 11a-methanoepoxy prostaglandin F2a)-induced contraction was examined in endothelium-intact (E+) and denuded (E-) rat pulmonary artery rings. Artery rings were mounted on a wire myograph under a tension of 7–7.5 mN at 37°C and gassed with 95% O2/5% CO2. Isometric recording was made by using Powerlab data collection and Chart 5 software.

Original languageEnglish
Pages (from-to)581-596
Number of pages16
JournalBritish Journal of Pharmacology
Volume157
Issue number4
DOIs
Publication statusPublished - 1 Jun 2009

Keywords

  • chloride channels
  • endothelium
  • thromboxane A2
  • rat pulmonary arteries

Fingerprint Dive into the research topics of 'Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium'. Together they form a unique fingerprint.

Cite this