Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium

C. McKenzie; Allan MacDonald; Angus M. Shaw

doi:10.1111/j.1476-5381.2008.00084.x

Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium

C. McKenzie, Allan MacDonald, Angus M. Shaw

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Thromboxane A2 and endothelial dysfunction are implicated in the development of pulmonary hypertension. The receptor-transduction pathway for U46619 (9,11-dideoxy-9a, 11a-methanoepoxy prostaglandin F2a)-induced contraction was examined in endothelium-intact (E+) and denuded (E-) rat pulmonary artery rings. Artery rings were mounted on a wire myograph under a tension of 7–7.5 mN at 37°C and gassed with 95% O2/5% CO2. Isometric recording was made by using Powerlab data collection and Chart 5 software.

Original language	English
Pages (from-to)	581-596
Number of pages	16
Journal	British Journal of Pharmacology
Volume	157
Issue number	4
DOIs	https://doi.org/10.1111/j.1476-5381.2008.00084.x
Publication status	Published - 1 Jun 2009

Keywords

chloride channels
endothelium
thromboxane A2
rat pulmonary arteries

Documents and Links

10.1111/j.1476-5381.2008.00084.x

http://researchonline.gcu.ac.uk/sls/284

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title = "Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium",

abstract = "Thromboxane A2 and endothelial dysfunction are implicated in the development of pulmonary hypertension. The receptor-transduction pathway for U46619 (9,11-dideoxy-9a, 11a-methanoepoxy prostaglandin F2a)-induced contraction was examined in endothelium-intact (E+) and denuded (E-) rat pulmonary artery rings. Artery rings were mounted on a wire myograph under a tension of 7–7.5 mN at 37°C and gassed with 95% O2/5% CO2. Isometric recording was made by using Powerlab data collection and Chart 5 software.",

keywords = "chloride channels, endothelium, thromboxane A2, rat pulmonary arteries",

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note = "Originally published in: British Journal of Pharmacology (2009), 157 (4), pp.581-596.",

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T1 - Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium

AU - McKenzie, C.

AU - MacDonald, Allan

AU - Shaw, Angus M.

N1 - Originally published in: British Journal of Pharmacology (2009), 157 (4), pp.581-596.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Thromboxane A2 and endothelial dysfunction are implicated in the development of pulmonary hypertension. The receptor-transduction pathway for U46619 (9,11-dideoxy-9a, 11a-methanoepoxy prostaglandin F2a)-induced contraction was examined in endothelium-intact (E+) and denuded (E-) rat pulmonary artery rings. Artery rings were mounted on a wire myograph under a tension of 7–7.5 mN at 37°C and gassed with 95% O2/5% CO2. Isometric recording was made by using Powerlab data collection and Chart 5 software.

AB - Thromboxane A2 and endothelial dysfunction are implicated in the development of pulmonary hypertension. The receptor-transduction pathway for U46619 (9,11-dideoxy-9a, 11a-methanoepoxy prostaglandin F2a)-induced contraction was examined in endothelium-intact (E+) and denuded (E-) rat pulmonary artery rings. Artery rings were mounted on a wire myograph under a tension of 7–7.5 mN at 37°C and gassed with 95% O2/5% CO2. Isometric recording was made by using Powerlab data collection and Chart 5 software.

KW - chloride channels

KW - endothelium

KW - thromboxane A2

KW - rat pulmonary arteries

U2 - 10.1111/j.1476-5381.2008.00084.x

DO - 10.1111/j.1476-5381.2008.00084.x

M3 - Article

VL - 157

SP - 581

EP - 596

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 4

ER -