Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5-HT1B receptor

C. McKenzie; V. R. Alapati; Allan MacDonald; Angus M. Shaw

doi:10.1111/j.1476-5381.2009.00519.x

Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5-HT1B receptor

C. McKenzie, V. R. Alapati, Allan MacDonald, Angus M. Shaw

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

5-HT1B receptors may have a role in pulmonary hypertension. Their relationship with the activity of BKCa, a T-type voltage-operated calcium channel (VOCC) and cyclic nucleotide-mediated relaxation was examined. Ring segments of bovine pulmonary arteries were mounted in organ baths in modified Krebs–Henseleit buffer (37oC) under a tension of 20 mN and gassed with 95% O2/5% CO2. Isometric recordings were made using Chart 5 software.

Original language	English
Pages (from-to)	188-200
Number of pages	13
Journal	British Journal of Pharmacology
Volume	159
Issue number	1
DOIs	https://doi.org/10.1111/j.1476-5381.2009.00519.x
Publication status	Published - 1 Jan 2010

Keywords

bovine pulmonary vascular tone
pulmonary arteries
pharmacology

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10.1111/j.1476-5381.2009.00519.x

Cite this

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abstract = "5-HT1B receptors may have a role in pulmonary hypertension. Their relationship with the activity of BKCa, a T-type voltage-operated calcium channel (VOCC) and cyclic nucleotide-mediated relaxation was examined. Ring segments of bovine pulmonary arteries were mounted in organ baths in modified Krebs–Henseleit buffer (37oC) under a tension of 20 mN and gassed with 95% O2/5% CO2. Isometric recordings were made using Chart 5 software.",

keywords = "bovine pulmonary vascular tone, pulmonary arteries, pharmacology",

author = "C. McKenzie and Alapati, {V. R.} and Allan MacDonald and Shaw, {Angus M.}",

note = "Originally published in: British Journal of Pharmacology (2010), 159 (1), pp.188-200.",

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AU - Alapati, V. R.

AU - MacDonald, Allan

AU - Shaw, Angus M.

N1 - Originally published in: British Journal of Pharmacology (2010), 159 (1), pp.188-200.

PY - 2010/1/1

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N2 - 5-HT1B receptors may have a role in pulmonary hypertension. Their relationship with the activity of BKCa, a T-type voltage-operated calcium channel (VOCC) and cyclic nucleotide-mediated relaxation was examined. Ring segments of bovine pulmonary arteries were mounted in organ baths in modified Krebs–Henseleit buffer (37oC) under a tension of 20 mN and gassed with 95% O2/5% CO2. Isometric recordings were made using Chart 5 software.

AB - 5-HT1B receptors may have a role in pulmonary hypertension. Their relationship with the activity of BKCa, a T-type voltage-operated calcium channel (VOCC) and cyclic nucleotide-mediated relaxation was examined. Ring segments of bovine pulmonary arteries were mounted in organ baths in modified Krebs–Henseleit buffer (37oC) under a tension of 20 mN and gassed with 95% O2/5% CO2. Isometric recordings were made using Chart 5 software.

KW - bovine pulmonary vascular tone

KW - pulmonary arteries

KW - pharmacology

U2 - 10.1111/j.1476-5381.2009.00519.x

DO - 10.1111/j.1476-5381.2009.00519.x

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JF - British Journal of Pharmacology

IS - 1

ER -

Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5-HT1B receptor

Abstract

Keywords

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