Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5-HT1B receptor

C. McKenzie, V. R. Alapati, Allan MacDonald, Angus M. Shaw

Research output: Contribution to journalArticle

Abstract

5-HT1B receptors may have a role in pulmonary hypertension. Their relationship with the activity of BKCa, a T-type voltage-operated calcium channel (VOCC) and cyclic nucleotide-mediated relaxation was examined. Ring segments of bovine pulmonary arteries were mounted in organ baths in modified Krebs–Henseleit buffer (37oC) under a tension of 20 mN and gassed with 95% O2/5% CO2. Isometric recordings were made using Chart 5 software.

Original languageEnglish
Pages (from-to)188-200
Number of pages13
JournalBritish Journal of Pharmacology
Volume159
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • bovine pulmonary vascular tone
  • pulmonary arteries
  • pharmacology

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