5-HT1B receptors may have a role in pulmonary hypertension. Their relationship with the activity of BKCa, a T-type voltage-operated calcium channel (VOCC) and cyclic nucleotide-mediated relaxation was examined. Ring segments of bovine pulmonary arteries were mounted in organ baths in modified Krebs–Henseleit buffer (37oC) under a tension of 20 mN and gassed with 95% O2/5% CO2. Isometric recordings were made using Chart 5 software.
- bovine pulmonary vascular tone
- pulmonary arteries