Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy

Ross T. Aitchison, Laura Ward, Graeme J. Kennedy, Xinhua Shu, David C. Mansfield, Uma Shahani

Research output: Contribution to journalArticle

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Abstract

Aims:Diabetes mellitus affects about 6% of the world’s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants’ mean glycated haemoglobin (HbA1c) level (±SD) was 7.2 ± 0.6% in the diabetic group and 5.5 ±0.4% in the non-diabetic group. Raw haemodynamic data were normalized to baseline, and the last 15 s of data from each ‘stimulus on’ and ‘stimulus off’ condition were averaged over seven duty cycles for each participant.Results: There were statistically significant differences in ¿[HbO] and ¿[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type-1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type-2 counterparts. There was also a linear relationship between both ¿[HbO] and ¿[HbR] as a function of HbA1clevel (p < 0.0005).Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ¿[HbO] and decrease in ¿[HbR] appears to be correlated with HbA1clevel.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalActa Diabetologica
Volume55
Issue number11
Early online date6 Aug 2018
DOIs
Publication statusPublished - Nov 2018

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Photic Stimulation
Near-Infrared Spectroscopy
Blood Vessels
Hemodynamics
Oxyhemoglobins
Glycosylated Hemoglobin A
Visual Cortex
Type 1 Diabetes Mellitus
Diabetes Mellitus
Chronic Disease
Population

Keywords

  • haemodynamic response · Functional near-infrared spectroscopy · Visual cortex · Diabetes · Autonomic dysfunction

Cite this

Aitchison, Ross T. ; Ward, Laura ; Kennedy, Graeme J. ; Shu, Xinhua ; Mansfield, David C. ; Shahani, Uma. / Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy. In: Acta Diabetologica. 2018 ; Vol. 55, No. 11. pp. 1-9.
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title = "Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy",
abstract = "Aims:Diabetes mellitus affects about 6{\%} of the world’s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants’ mean glycated haemoglobin (HbA1c) level (±SD) was 7.2 ± 0.6{\%} in the diabetic group and 5.5 ±0.4{\%} in the non-diabetic group. Raw haemodynamic data were normalized to baseline, and the last 15 s of data from each ‘stimulus on’ and ‘stimulus off’ condition were averaged over seven duty cycles for each participant.Results: There were statistically significant differences in ¿[HbO] and ¿[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type-1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type-2 counterparts. There was also a linear relationship between both ¿[HbO] and ¿[HbR] as a function of HbA1clevel (p < 0.0005).Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ¿[HbO] and decrease in ¿[HbR] appears to be correlated with HbA1clevel.",
keywords = "haemodynamic response · Functional near-infrared spectroscopy · Visual cortex · Diabetes · Autonomic dysfunction",
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Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy. / Aitchison, Ross T.; Ward, Laura; Kennedy, Graeme J.; Shu, Xinhua; Mansfield, David C.; Shahani, Uma.

In: Acta Diabetologica, Vol. 55, No. 11, 11.2018, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy

AU - Aitchison, Ross T.

AU - Ward, Laura

AU - Kennedy, Graeme J.

AU - Shu, Xinhua

AU - Mansfield, David C.

AU - Shahani, Uma

N1 - Acceptance from webpage OA article

PY - 2018/11

Y1 - 2018/11

N2 - Aims:Diabetes mellitus affects about 6% of the world’s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants’ mean glycated haemoglobin (HbA1c) level (±SD) was 7.2 ± 0.6% in the diabetic group and 5.5 ±0.4% in the non-diabetic group. Raw haemodynamic data were normalized to baseline, and the last 15 s of data from each ‘stimulus on’ and ‘stimulus off’ condition were averaged over seven duty cycles for each participant.Results: There were statistically significant differences in ¿[HbO] and ¿[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type-1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type-2 counterparts. There was also a linear relationship between both ¿[HbO] and ¿[HbR] as a function of HbA1clevel (p < 0.0005).Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ¿[HbO] and decrease in ¿[HbR] appears to be correlated with HbA1clevel.

AB - Aims:Diabetes mellitus affects about 6% of the world’s population, and the chronic complications of the disease may result in macro- and micro-vascular changes. The purpose of the current study was to shed light on visual cortical oxygenation in diabetic individuals. We then aimed to compare the haemodynamic response (HDR) to visual stimulation with glycaemic control, given the likelihood of diabetic individuals suffering from such macro- and micro-vascular insult.Methodology: Thirty participants took part in this explorative study, fifteen of whom had diabetes and fifteen of whom were non-diabetic controls. The HDR, measured as concentrations of oxyhaemoglobin [HbO] and deoxyhaemoglobin [HbR], to visual stimulation was recorded over the primary visual cortex (V1) using a dual-channel oximeter. The stimulus comprised a pattern-reversal checkerboard presented in a block design. Participants’ mean glycated haemoglobin (HbA1c) level (±SD) was 7.2 ± 0.6% in the diabetic group and 5.5 ±0.4% in the non-diabetic group. Raw haemodynamic data were normalized to baseline, and the last 15 s of data from each ‘stimulus on’ and ‘stimulus off’ condition were averaged over seven duty cycles for each participant.Results: There were statistically significant differences in ¿[HbO] and ¿[HbR] to visual stimulation between diabetic and non-diabetic groups (p < 0.05). In the diabetic group, individuals with type-1 diabetes displayed an increased [HbO] (p < 0.01) and decreased [HbR] (p < 0.05) compared to their type-2 counterparts. There was also a linear relationship between both ¿[HbO] and ¿[HbR] as a function of HbA1clevel (p < 0.0005).Conclusions: Our findings suggest that fNIRS can be used as a quantitative measure of cortical oxygenation in diabetes. Diabetic individuals have a larger HDR to visual stimulation compared to non-diabetic individuals. This increase in ¿[HbO] and decrease in ¿[HbR] appears to be correlated with HbA1clevel.

KW - haemodynamic response · Functional near-infrared spectroscopy · Visual cortex · Diabetes · Autonomic dysfunction

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DO - 10.1007/s00592-018-1200-5

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