Measures of quality of life of people with neurogenic overactive bladder: a systematic review of psychometric properties

Mohammed Usman Ali, Kenneth N.K. Fong, Priya Kannan*, Stanley John Winser, Umar Muhammad Bello, Dauda Salihu, Georg S. Kranz

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


To identify psychometrically robust quality-of-life (QOL) outcome measures for evaluating QOL among people with neurogenic overactive bladder (OAB).

Study design:
Electronic databases (CINAHL, EMBASE, MEDLINE, Scopus and Web of Science) were searched from inception to January 2023. Two independent reviewers participated in study screening, data extraction and quality appraisal. Studies were included if they validated at least one psychometric property of a QOL outcome measure among adults (age ≥18 years) with neurogenic OAB. The COnsensus-based Standards for selecting health status Measurement INstruments (COSMIN) checklist and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool were used to evaluate the methodological quality and quality of evidence, respectively, for each included study.

Database searches identified 47 studies that tested the psychometric properties of 15 QOL measures in a total of 19,994 participants with stroke, spinal cord injury, Parkinson's disease or multiple sclerosis. The Incontinence Quality of Life Questionnaire (I-QOL), King’s Health Questionnaire, Overactive Bladder Questionnaire and Qualiveen were the best validated measures, with strong reliability, validity and responsiveness. I-QOL was the most robust, cross-culturally administered and psychometrically strong measure. The COSMIN checklist indicated sufficient methodological quality for 70% of measures, and the modified GRADE tool indicated quality of evidence ranging from moderate (67%) to high (33%).

This review identified the I-QOL as a culturally diverse measure with robust reliability, validity and responsiveness for assessing QOL among people with neurogenic OAB. These findings are supported by studies with good methodological quality (COSMIN) and high-quality evidence (GRADE).
Original languageEnglish
Pages (from-to)40-57
Number of pages18
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Early online date10 Nov 2023
Publication statusPublished - Jan 2024


  • reliability
  • quality of life
  • overactive bladder
  • psychometric properties
  • validity
  • Validity
  • Outcome measures
  • Overactive bladder
  • Reliability
  • Psychometric properties
  • Quality of life

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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