MAP kinase signalling pathways in cancer

A. S. Dhillon, Suzanne Hagan, O. Rath, W. Kolch

Research output: Contribution to journalArticlepeer-review

2313 Citations (Scopus)


Cancer can be perceived as a disease of communication between and within cells. The aberrations are pleiotropic, but mitogen-activated protein kinase (MAPK) pathways feature prominently. Here, we discuss recent findings and hypotheses on the role of MAPK pathways in cancer. Cancerous mutations in MAPK pathways are frequently mostly affecting Ras and B-Raf in the extracellular signal-regulated kinase pathway. Stress-activated pathways, such as Jun N-terminal kinase and p38, largely seem to counteract malignant transformation. The balance and integration between these signals may widely vary in different tumours, but are important for the outcome and the sensitivity to drug therapy.
Original languageEnglish
Pages (from-to)3279-3290
Number of pages12
Issue number22
Publication statusPublished - May 2007


  • MAPK
  • signal transduction
  • cancer
  • oncogenes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine


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