Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension

Medicine & Life Sciences

• Fluvastatin 86%
• Adventitia 72%
• Pulmonary Hypertension 59%
• Fibroblasts 44%
• Phenotype 36%
• p38 Mitogen-Activated Protein Kinases 35%
• Lung 32%
• Pulmonary Artery 31%
• Hydroxymethylglutaryl-CoA Reductase Inhibitors 24%
• Mitogens 17%
• Coculture Techniques 17%
• Smooth Muscle Myocytes 15%
• treprostinil 14%
• Bosentan 12%
• Sildenafil Citrate 10%
• Vascular Remodeling 10%
• Protein Kinase Inhibitors 9%
• Conditioned Culture Medium 8%
• Global Health 8%
• Lung Diseases 7%
• Cattle 6%
• Hypoxia 6%
• Cholesterol 6%
• Animal Models 6%
• Public Health 6%
• Phosphorylation 5%
• Cell Proliferation 5%
• Animals 4%
• Therapeutics 2%

Chemical Compounds

• Fluvastatin 100%
• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 43%
• Mitogen 42%
• Treprostinil 32%
• Bosentan 26%
• EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor 24%
• Sildenafil 22%
• Conditioned Culture Medium 22%
• Proliferative 19%
• Protein 18%
• Cholesterol 13%