Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

Linda Scobie; Vered  Padler-Karavani; Stephanie  Le Bas-Bernardet; Claire Crossan; Josef  Blaha; Magda  Matouskova; Ralph D.  Hector; Emanuele  Cozzi; Bernard  Vanhove; Beatrice Charreau; Gilles  Blancho; Ludovic Bourdais; Mariachiara  Tallacchini; Juan M.  Ribes; Hai  Yu; Xi  Chen; Jitka  Kracikova; Ludomir  Broz; Jiri  Hejnar; Pavel  Vesely; Yasuhiro Takeuchi; Ajit  Varki; Jean-Paul  Soulillou

doi:10.4049/jimmunol.1301195

Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

Linda Scobie, Vered Padler-Karavani, Stephanie Le Bas-Bernardet, Claire Crossan, Josef Blaha, Magda Matouskova, Ralph D. Hector, Emanuele Cozzi, Bernard Vanhove, Beatrice Charreau, Gilles Blancho, Ludovic Bourdais, Mariachiara Tallacchini, Juan M. Ribes, Hai Yu, Xi Chen, Jitka Kracikova, Ludomir Broz, Jiri Hejnar, Pavel VeselyYasuhiro Takeuchi, Ajit Varki, Jean-Paul Soulillou

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings for up to 8 wk for the presence of PERV as well as for the level and nature of their long term (maximum, 34 y) immune response against pig Ags.

Original language	English
Pages (from-to)	2907-2915
Number of pages	9
Journal	Journal of Immunology
Volume	191
Issue number	6
Early online date	14 Sept 2013
DOIs	https://doi.org/10.4049/jimmunol.1301195
Publication status	Published - Sept 2013

Keywords

immunology
IgG
porcine endogenous retrovirus
xenotransplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Documents and Links

10.4049/jimmunol.1301195

Cite this

Scobie, L., Padler-Karavani, V., Le Bas-Bernardet, S., Crossan, C., Blaha, J., Matouskova, M., Hector, R. D., Cozzi, E., Vanhove, B., Charreau, B., Blancho, G., Bourdais, L., Tallacchini, M., Ribes, J. M., Yu, H., Chen, X., Kracikova, J., Broz, L., Hejnar, J., ... Soulillou, J-P. (2013). Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts. Journal of Immunology, 191(6), 2907-2915. https://doi.org/10.4049/jimmunol.1301195

@article{ed319261df8b49df9eefe41bcf9d5197,

title = "Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts",

abstract = "Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings for up to 8 wk for the presence of PERV as well as for the level and nature of their long term (maximum, 34 y) immune response against pig Ags.",

keywords = "immunology, IgG, porcine endogenous retrovirus , xenotransplantation",

author = "Linda Scobie and Vered Padler-Karavani and {Le Bas-Bernardet}, Stephanie and Claire Crossan and Josef Blaha and Magda Matouskova and Hector, {Ralph D.} and Emanuele Cozzi and Bernard Vanhove and Beatrice Charreau and Gilles Blancho and Ludovic Bourdais and Mariachiara Tallacchini and Ribes, {Juan M.} and Hai Yu and Xi Chen and Jitka Kracikova and Ludomir Broz and Jiri Hejnar and Pavel Vesely and Yasuhiro Takeuchi and Ajit Varki and Jean-Paul Soulillou",

year = "2013",

month = sep,

doi = "10.4049/jimmunol.1301195",

language = "English",

volume = "191",

pages = "2907--2915",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "6",

}

Scobie, L, Padler-Karavani, V, Le Bas-Bernardet, S, Crossan, C, Blaha, J, Matouskova, M, Hector, RD, Cozzi, E, Vanhove, B, Charreau, B, Blancho, G, Bourdais, L, Tallacchini, M, Ribes, JM, Yu, H, Chen, X, Kracikova, J, Broz, L, Hejnar, J, Vesely, P, Takeuchi, Y, Varki, A & Soulillou, J-P 2013, 'Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts', Journal of Immunology, vol. 191, no. 6, pp. 2907-2915. https://doi.org/10.4049/jimmunol.1301195

TY - JOUR

T1 - Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

AU - Scobie, Linda

AU - Padler-Karavani, Vered

AU - Le Bas-Bernardet, Stephanie

AU - Crossan, Claire

AU - Blaha, Josef

AU - Matouskova, Magda

AU - Hector, Ralph D.

AU - Cozzi, Emanuele

AU - Vanhove, Bernard

AU - Charreau, Beatrice

AU - Blancho, Gilles

AU - Bourdais, Ludovic

AU - Tallacchini, Mariachiara

AU - Ribes, Juan M.

AU - Yu, Hai

AU - Chen, Xi

AU - Kracikova, Jitka

AU - Broz, Ludomir

AU - Hejnar, Jiri

AU - Vesely, Pavel

AU - Takeuchi, Yasuhiro

AU - Varki, Ajit

AU - Soulillou, Jean-Paul

PY - 2013/9

Y1 - 2013/9

N2 - Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings for up to 8 wk for the presence of PERV as well as for the level and nature of their long term (maximum, 34 y) immune response against pig Ags.

AB - Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings for up to 8 wk for the presence of PERV as well as for the level and nature of their long term (maximum, 34 y) immune response against pig Ags.

KW - immunology

KW - IgG

KW - porcine endogenous retrovirus

KW - xenotransplantation

U2 - 10.4049/jimmunol.1301195

DO - 10.4049/jimmunol.1301195

M3 - Article

SN - 0022-1767

VL - 191

SP - 2907

EP - 2915

JO - Journal of Immunology

JF - Journal of Immunology

IS - 6

ER -

Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

Abstract

Keywords

UN SDGs

Documents and Links

Fingerprint

Cite this