Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts

Linda Scobie, Vered Padler-Karavani, Stephanie Le Bas-Bernardet, Claire Crossan, Josef Blaha, Magda Matouskova, Ralph D. Hector, Emanuele Cozzi, Bernard Vanhove, Beatrice Charreau, Gilles Blancho, Ludovic Bourdais, Mariachiara Tallacchini, Juan M. Ribes, Hai Yu, Xi Chen, Jitka Kracikova, Ludomir Broz, Jiri Hejnar, Pavel VeselyYasuhiro Takeuchi, Ajit Varki, Jean-Paul Soulillou

Research output: Contribution to journalArticle

Abstract

Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings for up to 8 wk for the presence of PERV as well as for the level and nature of their long term (maximum, 34 y) immune response against pig Ags.
Original languageEnglish
Pages (from-to)2907-2915
Number of pages9
JournalJournal of Immunology
Volume191
Issue number6
Early online date14 Sep 2013
DOIs
Publication statusPublished - Sep 2013

Keywords

  • immunology
  • IgG
  • porcine endogenous retrovirus
  • xenotransplantation

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