Long-range inhibitory mechanisms in the visual system are impaired in migraine sufferers

Doreen Wagner, Velitchko Manahilov, Gael Gordon, Peter Storch

Research output: Contribution to journalArticle


After viewing dynamic noise surrounding a homogeneous grey patch (artificial scotoma), observers perceive a prolonged twinkling-noise after-image within the unstimulated area. It has been suggested that noise-stimulated neurons induce a long-range inhibition in neurons within the artificial scotoma, which generates a rebound signal perceived as twinkling noise following noise termination. We used this paradigm to test whether migraineurs have enhanced excitability or weakened inhibition.
Original languageEnglish
Pages (from-to)1071-1075
Number of pages5
JournalCephalalgia : an international journal of headache
Issue number14
Publication statusPublished - Oct 2012



  • migraine
  • vision sciences
  • artificial scotoma

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