Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep

D. D.S. Collie, C. N. MacAldowie, A. D. Pemberton, Chris J. Woodall, N. McLean, C. Hodgson, M. W. Kennedy, H. R.P. Miller

    Research output: Contribution to journalArticle

    Abstract

    Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants. Understanding the factors that control tissue remodelling is a necessary step toward effective management and treatment of conditions that feature such pathology. This study found that mast cell phenotypic events occurring as a consequence of antigen challenge were limited to segments in which changes in BALF were characterized by neutrophil influx and increased local antibody production.

    Original languageEnglish
    Pages (from-to)1636-1647
    Number of pages12
    JournalClinical and Experimental Allergy
    Volume31
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2001

    Keywords

    • immune response
    • inflammatory response
    • transforming growth factor beta-1 (TGF-ß1)

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  • Cite this

    Collie, D. D. S., MacAldowie, C. N., Pemberton, A. D., Woodall, C. J., McLean, N., Hodgson, C., Kennedy, M. W., & Miller, H. R. P. (2001). Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep. Clinical and Experimental Allergy, 31(10), 1636-1647. https://doi.org/10.1046/j.1365-2222.2001.01225.x