Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep

D. D.S. Collie; C. N. MacAldowie; A. D. Pemberton; Chris J. Woodall; N. McLean; C. Hodgson; M. W. Kennedy; H. R.P. Miller

doi:10.1046/j.1365-2222.2001.01225.x

Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep

D. D.S. Collie, C. N. MacAldowie, A. D. Pemberton, Chris J. Woodall, N. McLean, C. Hodgson, M. W. Kennedy, H. R.P. Miller

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants. Understanding the factors that control tissue remodelling is a necessary step toward effective management and treatment of conditions that feature such pathology. This study found that mast cell phenotypic events occurring as a consequence of antigen challenge were limited to segments in which changes in BALF were characterized by neutrophil influx and increased local antibody production.

Original language	English
Pages (from-to)	1636-1647
Number of pages	12
Journal	Clinical and Experimental Allergy
Volume	31
Issue number	10
DOIs	https://doi.org/10.1046/j.1365-2222.2001.01225.x
Publication status	Published - 1 Oct 2001

Keywords

immune response
inflammatory response
transforming growth factor beta-1 (TGF-ß1)

Documents and Links

10.1046/j.1365-2222.2001.01225.x

http://researchonline.gcu.ac.uk/sls/141

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title = "Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep",

abstract = "Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants. Understanding the factors that control tissue remodelling is a necessary step toward effective management and treatment of conditions that feature such pathology. This study found that mast cell phenotypic events occurring as a consequence of antigen challenge were limited to segments in which changes in BALF were characterized by neutrophil influx and increased local antibody production.",

keywords = "immune response, inflammatory response, transforming growth factor beta-1 (TGF-{\ss}1)",

author = "Collie, {D. D.S.} and MacAldowie, {C. N.} and Pemberton, {A. D.} and Woodall, {Chris J.} and N. McLean and C. Hodgson and Kennedy, {M. W.} and Miller, {H. R.P.}",

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Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep. / Collie, D. D.S.; MacAldowie, C. N.; Pemberton, A. D.; Woodall, Chris J.; McLean, N.; Hodgson, C.; Kennedy, M. W.; Miller, H. R.P.

In: Clinical and Experimental Allergy, Vol. 31, No. 10, 01.10.2001, p. 1636-1647.

Research output: Contribution to journal › Article › peer-review

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T1 - Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep

AU - Collie, D. D.S.

AU - MacAldowie, C. N.

AU - Pemberton, A. D.

AU - Woodall, Chris J.

AU - McLean, N.

AU - Hodgson, C.

AU - Kennedy, M. W.

AU - Miller, H. R.P.

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AB - Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants. Understanding the factors that control tissue remodelling is a necessary step toward effective management and treatment of conditions that feature such pathology. This study found that mast cell phenotypic events occurring as a consequence of antigen challenge were limited to segments in which changes in BALF were characterized by neutrophil influx and increased local antibody production.

KW - immune response

KW - inflammatory response

KW - transforming growth factor beta-1 (TGF-ß1)

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DO - 10.1046/j.1365-2222.2001.01225.x

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