Abstract
Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants. Understanding the factors that control tissue remodelling is a necessary step toward effective management and treatment of conditions that feature such pathology. This study found that mast cell phenotypic events occurring as a consequence of antigen challenge were limited to segments in which changes in BALF were characterized by neutrophil influx and increased local antibody production.
Original language | English |
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Pages (from-to) | 1636-1647 |
Number of pages | 12 |
Journal | Clinical and Experimental Allergy |
Volume | 31 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2001 |
Keywords
- immune response
- inflammatory response
- transforming growth factor beta-1 (TGF-ß1)