Liposomal amphotericin b displays rapid dose-dependent activity against Candida albicans Biofilms

Gordon Ramage; Anto Jose; Leighann Sherry; David F. Lappin; Brian Jones; Craig Williams

doi:10.1128/AAC.02344-12

Liposomal amphotericin b displays rapid dose-dependent activity against Candida albicans Biofilms

Gordon Ramage^*, Anto Jose, Leighann Sherry, David F. Lappin, Brian Jones, Craig Williams

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration- dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.

Original language	English
Pages (from-to)	2369-2371
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	5
Early online date	11 Apr 2013
DOIs	https://doi.org/10.1128/AAC.02344-12
Publication status	Published - May 2013
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.02344-12

Cite this

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abstract = "Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration- dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.",

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AU - Ramage, Gordon

AU - Jose, Anto

AU - Sherry, Leighann

AU - Lappin, David F.

AU - Jones, Brian

AU - Williams, Craig

PY - 2013/5

Y1 - 2013/5

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AB - Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration- dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.

U2 - 10.1128/AAC.02344-12

DO - 10.1128/AAC.02344-12

M3 - Article

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AN - SCOPUS:84876204716

SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Liposomal amphotericin b displays rapid dose-dependent activity against Candida albicans Biofilms

Abstract

ASJC Scopus subject areas

UN SDGs

Documents and Links

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