Leucocyte mobilization and release of neutrophil elastase following acute insulin‐induced hypoglycaemia in normal humans

A. Collier*, A. W. Patrick, D. A. Hepburn, D. Bell, M. Jackson, J. Dawes, B. M. Frier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Insulin‐induced hypoglycaemia in humans is associated with the rapid mobilization of leucocytes in peripheral blood. The aim of the present study was to determine whether neutrophil activation, manifested in plasma by neutrophil elastase concentration, occurs in response to insulin‐induced hypoglycaemia. Acute hypoglycaemia (mean blood glucose 1.3 ± 0.2 mmol I−1; mean ± SD) was induced with intravenous insulin in 15 normal human subjects, and provoked an increase in the neutrophil count from 3.4 (range 1.9‐6.5) to 10.7 (9.4–16.3) × 109 I−1 (p<0.001), and in the total leucocyte counts from 5.7 (4.1–8.1) to 12.8 (11.3–18.6) × 109 I−1 (p<0.001), with associated elevations in plasma neutrophil elastase concentration from 21 (12–34) to 29 (14–70) μ‐g I−1 (p<0.05), and in total neutrophil elastase concentration from 5.90 (3.13‐8.20) to 25.20 (23.00–52.00) mg I−1 (p<0.001). As neutrophil elastase is implicated in the development of vascular disease, this rise in response to hypoglycaemia may be of pathological importance in insulin‐treated diabetic patients. 1990 Diabetes UK
Original languageEnglish
Pages (from-to)506-509
Number of pages4
JournalDiabetic Medicine
Volume7
Issue number6
DOIs
Publication statusPublished - Jul 1990
Externally publishedYes

Keywords

  • Hypoglycaemia
  • Leucocytes
  • Neutrophils
  • Plasma neutrophil elastase
  • Total neutrophil elastase

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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