Knee internal contact force in a varus malaligned phenotype in knee osteoarthritis (KOA)

A. Dell'Isola, S.L. Smith, M. S. Andersen, M. Steultjens

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Abstract

PurposeMultiple phenotypes characterized by different disease mechanisms have been hypothesized to explain the large variability in the knee osteoarthritis (KOA) population. The purpose of this study was: to estimate and compare the medial and lateral knee compression forces (CF) during gait of three subgroups of KOA subjects characterized by different alignment and cartilage disruption patterns.MethodsA secondary data analysis was conducted on a sample of 39 KOA subjects and 18 controls (C).The patients were classified in the different groups according to the following criteria:Varus medial disease (VMD) (12): varus alignment and predominant medial cartilage degeneration Varus generalized disease (VGD) (17): varus alignment and cartilage degeneration that extends to the lateral compartment.Neutral alignment (NA) (10): neutral alignment.The total, medial and lateral CF corrected for body weight were estimated using an inverse dynamics model (AnyBody Modeling System, AnyBody Technology) during stance.ResultsThe impulse of the medial compressive force (MCF) (overall effect of the CF over the stance) was significantly higher (P < 0.01) in the VMD compared to all the other groups. Peak MCF was higher in the VMD compared to all the other groups, but the difference reached significance only when compared to the VGD group (P < 0.05).The results of the regression analysis showed a significant relationship in the VMD group between alignment and impulse of the MCF (R2 = 0.62; P < 0.01). This relationship disappears in the other groups.ConclusionsThese findings suggest the existence of a phenotype characterized by increased MCF.
Original languageEnglish
Pages (from-to)2007-2013
JournalOsteoarthritis and Cartilage
Volume25
Issue number12
Early online date4 Sep 2017
DOIs
Publication statusPublished - Dec 2017

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Knee Osteoarthritis
Knee
Phenotype
Cartilage
Gait
Regression analysis
Dynamic models
Body Weight
Regression Analysis
Technology
Population

Keywords

  • knee
  • phenotype
  • biomechanics
  • contact force
  • osteoarthritis

Cite this

@article{498f726743d34150b6f56cb0fd63cab0,
title = "Knee internal contact force in a varus malaligned phenotype in knee osteoarthritis (KOA)",
abstract = "PurposeMultiple phenotypes characterized by different disease mechanisms have been hypothesized to explain the large variability in the knee osteoarthritis (KOA) population. The purpose of this study was: to estimate and compare the medial and lateral knee compression forces (CF) during gait of three subgroups of KOA subjects characterized by different alignment and cartilage disruption patterns.MethodsA secondary data analysis was conducted on a sample of 39 KOA subjects and 18 controls (C).The patients were classified in the different groups according to the following criteria:Varus medial disease (VMD) (12): varus alignment and predominant medial cartilage degeneration Varus generalized disease (VGD) (17): varus alignment and cartilage degeneration that extends to the lateral compartment.Neutral alignment (NA) (10): neutral alignment.The total, medial and lateral CF corrected for body weight were estimated using an inverse dynamics model (AnyBody Modeling System, AnyBody Technology) during stance.ResultsThe impulse of the medial compressive force (MCF) (overall effect of the CF over the stance) was significantly higher (P < 0.01) in the VMD compared to all the other groups. Peak MCF was higher in the VMD compared to all the other groups, but the difference reached significance only when compared to the VGD group (P < 0.05).The results of the regression analysis showed a significant relationship in the VMD group between alignment and impulse of the MCF (R2 = 0.62; P < 0.01). This relationship disappears in the other groups.ConclusionsThese findings suggest the existence of a phenotype characterized by increased MCF.",
keywords = "knee , phenotype, biomechanics, contact force, osteoarthritis",
author = "A. Dell'Isola and S.L. Smith and Andersen, {M. S.} and M. Steultjens",
note = "Acceptance email in SAN OA paper (accepted version only at time of validation) ET 26-10-17 Funding note: European Union's Seventh Framework Programme (FP7-PEOPLE-2013-ITN) under grant agreement no. 607510.",
year = "2017",
month = "12",
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language = "English",
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Knee internal contact force in a varus malaligned phenotype in knee osteoarthritis (KOA). / Dell'Isola, A.; Smith, S.L.; Andersen, M. S.; Steultjens, M.

In: Osteoarthritis and Cartilage, Vol. 25, No. 12, 12.2017, p. 2007-2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Knee internal contact force in a varus malaligned phenotype in knee osteoarthritis (KOA)

AU - Dell'Isola, A.

AU - Smith, S.L.

AU - Andersen, M. S.

AU - Steultjens, M.

N1 - Acceptance email in SAN OA paper (accepted version only at time of validation) ET 26-10-17 Funding note: European Union's Seventh Framework Programme (FP7-PEOPLE-2013-ITN) under grant agreement no. 607510.

PY - 2017/12

Y1 - 2017/12

N2 - PurposeMultiple phenotypes characterized by different disease mechanisms have been hypothesized to explain the large variability in the knee osteoarthritis (KOA) population. The purpose of this study was: to estimate and compare the medial and lateral knee compression forces (CF) during gait of three subgroups of KOA subjects characterized by different alignment and cartilage disruption patterns.MethodsA secondary data analysis was conducted on a sample of 39 KOA subjects and 18 controls (C).The patients were classified in the different groups according to the following criteria:Varus medial disease (VMD) (12): varus alignment and predominant medial cartilage degeneration Varus generalized disease (VGD) (17): varus alignment and cartilage degeneration that extends to the lateral compartment.Neutral alignment (NA) (10): neutral alignment.The total, medial and lateral CF corrected for body weight were estimated using an inverse dynamics model (AnyBody Modeling System, AnyBody Technology) during stance.ResultsThe impulse of the medial compressive force (MCF) (overall effect of the CF over the stance) was significantly higher (P < 0.01) in the VMD compared to all the other groups. Peak MCF was higher in the VMD compared to all the other groups, but the difference reached significance only when compared to the VGD group (P < 0.05).The results of the regression analysis showed a significant relationship in the VMD group between alignment and impulse of the MCF (R2 = 0.62; P < 0.01). This relationship disappears in the other groups.ConclusionsThese findings suggest the existence of a phenotype characterized by increased MCF.

AB - PurposeMultiple phenotypes characterized by different disease mechanisms have been hypothesized to explain the large variability in the knee osteoarthritis (KOA) population. The purpose of this study was: to estimate and compare the medial and lateral knee compression forces (CF) during gait of three subgroups of KOA subjects characterized by different alignment and cartilage disruption patterns.MethodsA secondary data analysis was conducted on a sample of 39 KOA subjects and 18 controls (C).The patients were classified in the different groups according to the following criteria:Varus medial disease (VMD) (12): varus alignment and predominant medial cartilage degeneration Varus generalized disease (VGD) (17): varus alignment and cartilage degeneration that extends to the lateral compartment.Neutral alignment (NA) (10): neutral alignment.The total, medial and lateral CF corrected for body weight were estimated using an inverse dynamics model (AnyBody Modeling System, AnyBody Technology) during stance.ResultsThe impulse of the medial compressive force (MCF) (overall effect of the CF over the stance) was significantly higher (P < 0.01) in the VMD compared to all the other groups. Peak MCF was higher in the VMD compared to all the other groups, but the difference reached significance only when compared to the VGD group (P < 0.05).The results of the regression analysis showed a significant relationship in the VMD group between alignment and impulse of the MCF (R2 = 0.62; P < 0.01). This relationship disappears in the other groups.ConclusionsThese findings suggest the existence of a phenotype characterized by increased MCF.

KW - knee

KW - phenotype

KW - biomechanics

KW - contact force

KW - osteoarthritis

U2 - 10.1016/j.joca.2017.08.010

DO - 10.1016/j.joca.2017.08.010

M3 - Article

VL - 25

SP - 2007

EP - 2013

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 12

ER -