Is fatigue associated with aerobic capacity and muscle strength in people with Multiple Sclerosis: a systematic review and meta-analysis

Scott Rooney, Leslie Wood, Fiona Moffat, Lorna Paul

Research output: Contribution to journalArticle

Abstract

Objective: Determine the relationship between self-reported fatigue and aerobic capacity and muscle strength in people with Multiple Sclerosis (MS).Data sources: Four databases (CINAHL, MEDLINE, ProQuest, and Web of Science Core Collections) were searched up to October 2018.Study selection: Cross-sectional or longitudinal studies that reported the association between self-reported fatigue and aerobic capacity or objectively measured muscle strength in people with MS were included. Data extraction: Study details, participant demographics, outcome measurement protocols, and the correlation coefficient derived from the association between fatigue and aerobic capacity or muscle strength at baseline was extracted, and methodological quality of included studies was assessed using the Joanna Briggs Institute Appraisal Checklist for Analytical Cross-sectional Studies.Data synthesis: Ten studies were identified, of which five examined the association between fatigue and aerobic capacity and seven examined the association between fatigue and muscle strength. Meta-analysis of the extracted correlation coefficients was performed using the Hedges-Olkin method, and pooled correlation coefficients demonstrated a moderate, negative association between fatigue and aerobic capacity (r = -0.471; 95% CI = -0.644, -0.251; p<0.001), and a weak, negative association between fatigue and muscle strength (r = -0.224; 95% CI = -0.399, -0.032; p = 0.022). Conclusions: The results of this meta-analysis suggest that higher levels of aerobic capacity are associated with lower fatigue. Therefore, this finding highlights the potential role of aerobic exercise interventions in managing fatigue. Conversely, the relationship between fatigue and muscle strength was weak and inconsistent, and further studies are required to examine the association between these variables.
Original languageEnglish
JournalArchives of Physical Medicine and Rehabilitation
Early online date6 Aug 2019
DOIs
Publication statusE-pub ahead of print - 6 Aug 2019

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Muscle Strength
Multiple Sclerosis
Fatigue
Meta-Analysis
Cross-Sectional Studies
Information Storage and Retrieval
Checklist
MEDLINE
Longitudinal Studies
Demography
Databases
Exercise

Keywords

  • fatigue
  • Multiple Sclerosis
  • muscle strength
  • rehabilitation

Cite this

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title = "Is fatigue associated with aerobic capacity and muscle strength in people with Multiple Sclerosis: a systematic review and meta-analysis",
abstract = "Objective: Determine the relationship between self-reported fatigue and aerobic capacity and muscle strength in people with Multiple Sclerosis (MS).Data sources: Four databases (CINAHL, MEDLINE, ProQuest, and Web of Science Core Collections) were searched up to October 2018.Study selection: Cross-sectional or longitudinal studies that reported the association between self-reported fatigue and aerobic capacity or objectively measured muscle strength in people with MS were included. Data extraction: Study details, participant demographics, outcome measurement protocols, and the correlation coefficient derived from the association between fatigue and aerobic capacity or muscle strength at baseline was extracted, and methodological quality of included studies was assessed using the Joanna Briggs Institute Appraisal Checklist for Analytical Cross-sectional Studies.Data synthesis: Ten studies were identified, of which five examined the association between fatigue and aerobic capacity and seven examined the association between fatigue and muscle strength. Meta-analysis of the extracted correlation coefficients was performed using the Hedges-Olkin method, and pooled correlation coefficients demonstrated a moderate, negative association between fatigue and aerobic capacity (r = -0.471; 95{\%} CI = -0.644, -0.251; p<0.001), and a weak, negative association between fatigue and muscle strength (r = -0.224; 95{\%} CI = -0.399, -0.032; p = 0.022). Conclusions: The results of this meta-analysis suggest that higher levels of aerobic capacity are associated with lower fatigue. Therefore, this finding highlights the potential role of aerobic exercise interventions in managing fatigue. Conversely, the relationship between fatigue and muscle strength was weak and inconsistent, and further studies are required to examine the association between these variables.",
keywords = "fatigue, Multiple Sclerosis, muscle strength, rehabilitation",
author = "Scott Rooney and Leslie Wood and Fiona Moffat and Lorna Paul",
note = "Acceptance in SAN AAM: apply 12m embargo ^not yet published 19/7/19 DC ^Removed temp holding embargo for Pure migration ET 6-9-19",
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doi = "10.1016/j.apmr.2019.06.014",
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AU - Rooney, Scott

AU - Wood, Leslie

AU - Moffat, Fiona

AU - Paul, Lorna

N1 - Acceptance in SAN AAM: apply 12m embargo ^not yet published 19/7/19 DC ^Removed temp holding embargo for Pure migration ET 6-9-19

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N2 - Objective: Determine the relationship between self-reported fatigue and aerobic capacity and muscle strength in people with Multiple Sclerosis (MS).Data sources: Four databases (CINAHL, MEDLINE, ProQuest, and Web of Science Core Collections) were searched up to October 2018.Study selection: Cross-sectional or longitudinal studies that reported the association between self-reported fatigue and aerobic capacity or objectively measured muscle strength in people with MS were included. Data extraction: Study details, participant demographics, outcome measurement protocols, and the correlation coefficient derived from the association between fatigue and aerobic capacity or muscle strength at baseline was extracted, and methodological quality of included studies was assessed using the Joanna Briggs Institute Appraisal Checklist for Analytical Cross-sectional Studies.Data synthesis: Ten studies were identified, of which five examined the association between fatigue and aerobic capacity and seven examined the association between fatigue and muscle strength. Meta-analysis of the extracted correlation coefficients was performed using the Hedges-Olkin method, and pooled correlation coefficients demonstrated a moderate, negative association between fatigue and aerobic capacity (r = -0.471; 95% CI = -0.644, -0.251; p<0.001), and a weak, negative association between fatigue and muscle strength (r = -0.224; 95% CI = -0.399, -0.032; p = 0.022). Conclusions: The results of this meta-analysis suggest that higher levels of aerobic capacity are associated with lower fatigue. Therefore, this finding highlights the potential role of aerobic exercise interventions in managing fatigue. Conversely, the relationship between fatigue and muscle strength was weak and inconsistent, and further studies are required to examine the association between these variables.

AB - Objective: Determine the relationship between self-reported fatigue and aerobic capacity and muscle strength in people with Multiple Sclerosis (MS).Data sources: Four databases (CINAHL, MEDLINE, ProQuest, and Web of Science Core Collections) were searched up to October 2018.Study selection: Cross-sectional or longitudinal studies that reported the association between self-reported fatigue and aerobic capacity or objectively measured muscle strength in people with MS were included. Data extraction: Study details, participant demographics, outcome measurement protocols, and the correlation coefficient derived from the association between fatigue and aerobic capacity or muscle strength at baseline was extracted, and methodological quality of included studies was assessed using the Joanna Briggs Institute Appraisal Checklist for Analytical Cross-sectional Studies.Data synthesis: Ten studies were identified, of which five examined the association between fatigue and aerobic capacity and seven examined the association between fatigue and muscle strength. Meta-analysis of the extracted correlation coefficients was performed using the Hedges-Olkin method, and pooled correlation coefficients demonstrated a moderate, negative association between fatigue and aerobic capacity (r = -0.471; 95% CI = -0.644, -0.251; p<0.001), and a weak, negative association between fatigue and muscle strength (r = -0.224; 95% CI = -0.399, -0.032; p = 0.022). Conclusions: The results of this meta-analysis suggest that higher levels of aerobic capacity are associated with lower fatigue. Therefore, this finding highlights the potential role of aerobic exercise interventions in managing fatigue. Conversely, the relationship between fatigue and muscle strength was weak and inconsistent, and further studies are required to examine the association between these variables.

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