Involvement of gap junctions in bradykinin induced relaxation of bovine pulmonary supernumerary arteries before and after inhibition of nitric oxide/guanylate cyclase

A. Tracey, Allan MacDonald, Angus M. Shaw

Research output: Contribution to journalArticle

Abstract

This study evaluated the possible contribution of gap junctions to the nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses elicited by bradykinin in bovine pulmonary supernumerary arteries. The data suggest that, in bovine pulmonary supernumerary arteries, gap junctions may, in part, facilitate the EDHF-mediated response, but not the NO-mediated response, to bradykinin. However, the additional involvement of an unidentifed endothelial relaxing factor cannot be excluded.

Original languageEnglish
JournalClinical Science
Publication statusPublished - Dec 2002

Keywords

  • gap junctions
  • guanylate cyclase
  • nitric oxide
  • pulmonary arteries

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