Involvement of gap junctions in bradykinin induced relaxation of bovine pulmonary supernumerary arteries before and after inhibition of nitric oxide/guanylate cyclase

A. Tracey; Allan MacDonald; Angus M. Shaw

Involvement of gap junctions in bradykinin induced relaxation of bovine pulmonary supernumerary arteries before and after inhibition of nitric oxide/guanylate cyclase

A. Tracey, Allan MacDonald, Angus M. Shaw

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

This study evaluated the possible contribution of gap junctions to the nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses elicited by bradykinin in bovine pulmonary supernumerary arteries. The data suggest that, in bovine pulmonary supernumerary arteries, gap junctions may, in part, facilitate the EDHF-mediated response, but not the NO-mediated response, to bradykinin. However, the additional involvement of an unidentifed endothelial relaxing factor cannot be excluded.

Original language	English
Journal	Clinical Science
Publication status	Published - Dec 2002

Keywords

gap junctions
guanylate cyclase
nitric oxide
pulmonary arteries

Cite this

@article{a78c69e8580349a3b2a04205d6632d32,

title = "Involvement of gap junctions in bradykinin induced relaxation of bovine pulmonary supernumerary arteries before and after inhibition of nitric oxide/guanylate cyclase",

abstract = "This study evaluated the possible contribution of gap junctions to the nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses elicited by bradykinin in bovine pulmonary supernumerary arteries. The data suggest that, in bovine pulmonary supernumerary arteries, gap junctions may, in part, facilitate the EDHF-mediated response, but not the NO-mediated response, to bradykinin. However, the additional involvement of an unidentifed endothelial relaxing factor cannot be excluded.",

keywords = "gap junctions, guanylate cyclase, nitric oxide, pulmonary arteries",

author = "A. Tracey and Allan MacDonald and Shaw, {Angus M.}",

note = "Originally published in: Clinical Science (2002), 103 (6), pp.553-557.",

year = "2002",

month = dec,

language = "English",

journal = "Clinical Science",

publisher = "Portland Press Ltd.",

}

TY - JOUR

T1 - Involvement of gap junctions in bradykinin induced relaxation of bovine pulmonary supernumerary arteries before and after inhibition of nitric oxide/guanylate cyclase

AU - Tracey, A.

AU - MacDonald, Allan

AU - Shaw, Angus M.

N1 - Originally published in: Clinical Science (2002), 103 (6), pp.553-557.

PY - 2002/12

Y1 - 2002/12

N2 - This study evaluated the possible contribution of gap junctions to the nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses elicited by bradykinin in bovine pulmonary supernumerary arteries. The data suggest that, in bovine pulmonary supernumerary arteries, gap junctions may, in part, facilitate the EDHF-mediated response, but not the NO-mediated response, to bradykinin. However, the additional involvement of an unidentifed endothelial relaxing factor cannot be excluded.

AB - This study evaluated the possible contribution of gap junctions to the nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated responses elicited by bradykinin in bovine pulmonary supernumerary arteries. The data suggest that, in bovine pulmonary supernumerary arteries, gap junctions may, in part, facilitate the EDHF-mediated response, but not the NO-mediated response, to bradykinin. However, the additional involvement of an unidentifed endothelial relaxing factor cannot be excluded.

KW - gap junctions

KW - guanylate cyclase

KW - nitric oxide

KW - pulmonary arteries

M3 - Article

JO - Clinical Science

JF - Clinical Science

ER -

Involvement of gap junctions in bradykinin induced relaxation of bovine pulmonary supernumerary arteries before and after inhibition of nitric oxide/guanylate cyclase

Abstract

Keywords

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