Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Joy Cuthberston; Steven Patterson; Finbarr O'Harte; Patrick  Bell

doi:10.1111/j.1464-5491.2009.02748.x

Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Joy Cuthberston, Steven Patterson, Finbarr O'Harte, Patrick Bell

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone and major component of the enteroinsular axis. Its therapeutic potential in human diabetes is limited by rapid degradation and inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes.

Original language	English
Pages (from-to)	649-654
Number of pages	6
Journal	Diabetic Medicine
Volume	26
Issue number	6
DOIs	https://doi.org/10.1111/j.1464-5491.2009.02748.x
Publication status	Published - Jun 2009

Keywords

type 2 diabetes
insulin
metformin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1464-5491.2009.02748.x

Cite this

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AU - O'Harte, Finbarr

AU - Bell, Patrick

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AB - Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone and major component of the enteroinsular axis. Its therapeutic potential in human diabetes is limited by rapid degradation and inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes.

KW - type 2 diabetes

KW - insulin

KW - metformin

U2 - 10.1111/j.1464-5491.2009.02748.x

DO - 10.1111/j.1464-5491.2009.02748.x

M3 - Article

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JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 6

ER -

Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Abstract

Keywords

UN SDGs

Documents and Links

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