Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Joy Cuthberston; Steven Patterson; Finbarr O'Harte; Patrick  Bell

doi:10.1111/j.1464-5491.2009.02748.x

Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Joy Cuthberston, Steven Patterson, Finbarr O'Harte, Patrick Bell

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone and major component of the enteroinsular axis. Its therapeutic potential in human diabetes is limited by rapid degradation and inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes.

Original language	English
Pages (from-to)	649-654
Number of pages	6
Journal	Diabetic Medicine
Volume	26
Issue number	6
DOIs	https://doi.org/10.1111/j.1464-5491.2009.02748.x
Publication status	Published - Jun 2009

Keywords

type 2 diabetes
insulin
metformin

Documents and Links

10.1111/j.1464-5491.2009.02748.x

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abstract = "Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone and major component of the enteroinsular axis. Its therapeutic potential in human diabetes is limited by rapid degradation and inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes.",

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