Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Joy Cuthberston, Steven Patterson, Finbarr O'Harte, Patrick Bell

Research output: Contribution to journalArticle

Abstract

Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone and major component of the enteroinsular axis. Its therapeutic potential in human diabetes is limited by rapid degradation and inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes.
Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalDiabetic Medicine
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Glucagon-Like Peptide 1
Metformin
Type 2 Diabetes Mellitus
Hormones
Food
Enzymes
Therapeutics

Keywords

  • type 2 diabetes
  • insulin
  • metformin

Cite this

Cuthberston, Joy ; Patterson, Steven ; O'Harte, Finbarr ; Bell, Patrick . / Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes. In: Diabetic Medicine. 2009 ; Vol. 26, No. 6. pp. 649-654.
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Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes. / Cuthberston, Joy; Patterson, Steven; O'Harte, Finbarr; Bell, Patrick .

In: Diabetic Medicine, Vol. 26, No. 6, 06.2009, p. 649-654.

Research output: Contribution to journalArticle

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