Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone and major component of the enteroinsular axis. Its therapeutic potential in human diabetes is limited by rapid degradation and inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes.
- type 2 diabetes
Cuthberston, J., Patterson, S., O'Harte, F., & Bell, P. (2009). Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes. Diabetic Medicine, 26(6), 649-654. https://doi.org/10.1111/j.1464-5491.2009.02748.x