Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes

Joy Cuthberston, Steven Patterson, Finbarr O'Harte, Patrick Bell

Research output: Contribution to journalArticle

Abstract

Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone and major component of the enteroinsular axis. Its therapeutic potential in human diabetes is limited by rapid degradation and inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4). We investigated the acute effects of metformin with and without food on DPP-4 activity in Type 2 diabetes.
Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalDiabetic Medicine
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • type 2 diabetes
  • insulin
  • metformin

Fingerprint Dive into the research topics of 'Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes'. Together they form a unique fingerprint.

  • Cite this