Interconversion of the National Institutes of Health Stroke Scale and Scandinavian Stroke Scale in acute stroke

Laura J. Gray, Myzoon Ali, Patrick D. Lyden, Philip M. W. Bath

    Research output: Contribution to journalArticle

    Abstract

    IntroductionThe National Institutes of Health Stroke Scale (NIHSS) and Scandinavian Stroke Scale (SSS) are both validated measures of neurologic impairment and have been used in many acute stroke trials. Methods for interconverting SSS and NIHSS are needed.
    MethodsConversion equations were developed using linear regression (both unadjusted, and adjusted for age and sex) using a random 50% of the data at both baseline and 90 days. The remaining 50% of data were used to test the accuracy of the models produced.
    ResultsData from 5 acute stroke trials (2004 patients) were included. Fitted models at baseline were NIHSS = 25.68 – 0.43 ∗ SSS ( R2 = 0.57, prediction error [PE] –0.2, P = .20), and SSS = 50.37 – 1.63 ∗ NIHSS ( R2 = 0.59, PE 0.2, P = .35). The 90-day models were NIHSS = 22.99 – 0.39 ∗ SSS ( R2 = 0.82, PE –0.3, P = .001), and SSS = 56.68 – 2.20 ∗ NIHSS ( R2 = 0.80, PE –0.4, P = .08). Adjustment did not materially improve the R2 values.
    ConclusionTotal scores for NIHSS and SSS may be interconverted with good precision; the mathematic conversion equations may prove useful in clinical practice and in comparison of data from observational studies and randomized trials.
    Original languageEnglish
    Pages (from-to)466-468
    Number of pages3
    JournalJournal of Stroke and Cerebrovascular Diseases
    Volume18
    Issue number6
    DOIs
    Publication statusPublished - Nov 2009

    Keywords

    • stroke
    • clinical trial

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