Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation

Aine McKillop; Nicola Duffy; John Lindsay; Brian Green; Steven Patterson; Finbarr O'Harte; Patrick  Bell; Peter  Flatt

doi:10.1530/EJE-09-0547

Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation

Aine McKillop, Nicola Duffy, John Lindsay, Brian Green, Steven Patterson, Finbarr O'Harte, Patrick Bell, Peter Flatt

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and methods Blood samples were collected from type 2 diabetic subjects (n=10, fasting glucose 9.36+/-1.2 mmol/l) following administration of oral nateglinide (120 mg) 10 min prior to a 75 g oral glucose load in a randomised crossover design.

Original language	English
Pages (from-to)	877-885
Number of pages	9
Journal	European Journal of Endocrinology
Volume	161
Issue number	6
DOIs	https://doi.org/10.1530/EJE-09-0547
Publication status	Published - Dec 2009

Keywords

diabetes
insulin secretion
nateglinide
postprandial hyperglycaemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1530/EJE-09-0547

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McKillop, A., Duffy, N., Lindsay, J., Green, B., Patterson, S., O'Harte, F., Bell, P., & Flatt, P. (2009). Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation. European Journal of Endocrinology, 161(6), 877-885. https://doi.org/10.1530/EJE-09-0547

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title = "Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation",

abstract = "Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and methods Blood samples were collected from type 2 diabetic subjects (n=10, fasting glucose 9.36+/-1.2 mmol/l) following administration of oral nateglinide (120 mg) 10 min prior to a 75 g oral glucose load in a randomised crossover design.",

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author = "Aine McKillop and Nicola Duffy and John Lindsay and Brian Green and Steven Patterson and Finbarr O'Harte and Patrick Bell and Peter Flatt",

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McKillop, A, Duffy, N, Lindsay, J, Green, B, Patterson, S, O'Harte, F, Bell, P & Flatt, P 2009, 'Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation', European Journal of Endocrinology, vol. 161, no. 6, pp. 877-885. https://doi.org/10.1530/EJE-09-0547

Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation. / McKillop, Aine; Duffy, Nicola; Lindsay, John et al.
In: European Journal of Endocrinology, Vol. 161, No. 6, 12.2009, p. 877-885.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation

AU - McKillop, Aine

AU - Duffy, Nicola

AU - Lindsay, John

AU - Green, Brian

AU - Patterson, Steven

AU - O'Harte, Finbarr

AU - Bell, Patrick

AU - Flatt, Peter

PY - 2009/12

Y1 - 2009/12

N2 - Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and methods Blood samples were collected from type 2 diabetic subjects (n=10, fasting glucose 9.36+/-1.2 mmol/l) following administration of oral nateglinide (120 mg) 10 min prior to a 75 g oral glucose load in a randomised crossover design.

AB - Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and methods Blood samples were collected from type 2 diabetic subjects (n=10, fasting glucose 9.36+/-1.2 mmol/l) following administration of oral nateglinide (120 mg) 10 min prior to a 75 g oral glucose load in a randomised crossover design.

KW - diabetes

KW - insulin secretion

KW - nateglinide

KW - postprandial hyperglycaemia

UR - https://www.scopus.com/pages/publications/72949089282

U2 - 10.1530/EJE-09-0547

DO - 10.1530/EJE-09-0547

M3 - Article

AN - SCOPUS:72949089282

SN - 0804-4643

VL - 161

SP - 877

EP - 885

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 6

ER -

Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation

Abstract

Keywords

UN SDGs

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