Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

Nigel Irwin*, Peter R. Flatt, Steven Patterson, Brian D. Green

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Much recent attention has focused on the GLP-1 receptor as a potential target for antidiabetic drugs. Enzyme resistant GLP-1 mimetics such as exenatide are now employed for the treatment of type 2 diabetes, but must be administered by injection. The present study has examined and compared the in vitro and in vivo metabolic actions of a small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline (DMB), with native GLP-1, exenatide and liraglutide. DMB significantly stimulated in vitro insulin secretion from BRIN-BD11 cells but with decreased molar potency compared to native GLP-1 or related mimetics. Administration of DMB in combination with glucose to mice significantly (P < 0.05) decreased the overall glucose excursion compared to controls. Exenatide and liraglutide evoked similar (P < 0.001) reductions of the overall glycaemic excursion, but were significantly (P < 0.001 and P < 0.05; respectively) more effective than DMB. These observations were associated with prominently (P < 0.05) enhanced glucose-mediated insulin release by exenatide and liraglutide, but not by DMB. Combined injection of DMB with either liraglutide or exenatide did not substantially improve glucose-lowering or insulin-releasing responses. However, administration of DMB in combination with exendin(9-39) did not impair its glucoregulatory actions. These results provide evidence to support the development and potential use of low molecular weight GLP-1 receptor agonists for the treatment of type 2 diabetes.

Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalEuropean Journal of Pharmacology
Volume628
Issue number1-3
DOIs
Publication statusPublished - 25 Feb 2010

Keywords

  • Glucagon-like peptide-1 (GLP-1)
  • Glucose homeostasis
  • Small molecule
  • Insulin secretion
  • Diabetes

ASJC Scopus subject areas

  • Pharmacology

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