Inputs and outputs of the lacrimal system: review of production and evaporative loss

Alan Tomlinson, Marshall G. Doane, Angus McFadyen

Research output: Contribution to journalArticle

Abstract

Meta-analyses were carried out of studies of tear production (by fluorophotometry, tear turnover rate [TTR]) and evaporation (from capture of fluid loss from the eye). TTR was reduced in dry eye relative to normal at 9.26 ± 5.08%/min (0.54 ± 0.28 µl/min) vs 16.19 ± 5.1%/min (1.03 ± 0.39 µl/min); with values of 7.71 ± 1.02%/min (0.4 ± 0.10 µl/min) in aqueous deficiency dry eye (ADDE) and 11.95 ± 4.25%/min (0.71 ± 0.25 µl/min) in evaporative dry eye (EDE). Evaporation was increased in dry eye at 21.05 ± 13.96 × 10-7g/cm2/s (0.21 ± 0.13 µl/min) vs 13.57 ± 6.52 × 10-7g/cm2/s (0.14 ± 0.07 µl/min) in normals; with values of 17.91 ± 10.49 × 10-7g/cm2/s (0.17 ± 0.1 µl/min) in ADDE and 25.34 ± 13.08 × 10-7g/cm2/s (0.26 ± 0.16 µl/min) in EDE.

Original languageEnglish
Pages (from-to)186-198
Number of pages13
JournalOcular Surface
Volume7
Issue number4
DOIs
Publication statusPublished - Oct 2009

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Keywords

  • tear production
  • vision sciences

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